M2 PHARMA-May 15, 2019-Noveome Biotherapeutics Publishes Further Preclinical Results Supporting the Neuroprotective Properties of ST266 in Retinal Ganglion Cells
In another study conducted on Type-I diabetic patients, without retinopathy, similar difference in RNFL thickness was found.14 In another study conducted on Type-I diabetic children, without retinopathy, it was found that RNFL and ganglion cell
thickness was far less as compared to normal children.15 Thus there is evidence of neuro generative effect of DM on ganglion cells
before the development of vascular component of diabetic retinopathy.
In HSCR, for example, obstructive physiology in the aganglionic segment is associated with upstream distension, inflammation, and smooth muscle hypertrophy, and could conceivably promote submucosal ganglion cell
Moreover, the different activity pattern is linked not only to photoreceptor density and rod/cone ratio, but also to shape and depth of the fovea and number and distribution of Retinal Ganglion Cells
(RGCs) (Oehme, 1961).
Counts in the Cochleae of Patients with Normal Audiograms.
Visual dysfunction in multiple sclerosis correlates better with optical coherence tomography derived estimates of macular ganglion cell
layer thickness than peripapillary retinal nerve fiber layer thickness.
Each patient was scanned using two patterns, including an ONH scan and ganglion cell
complex (GCC) scan.
Ganglioneuromatosis polyposis is distinguished by numerous sessile or pedunculated mucosal and/or submucosal lesions showing greater variability in neural, supportive, and ganglion cell
content with demarcation compared to polypoid ganglioneuromas.
The GLV can best detect diffuse ganglion cell
With the ETDRS scan nine macular areas  (which include a central 1 mm circle representing the fovea, and inner and outer rings measuring 3 mm and 6 mm in diameter, respectively), central and average thickness plus macular volume are analyzed; the TSNIT scan provides automated separate measurements of different retinal layers: retinal nerve fiber layer (RNFL) (between the inner limiting membrane (ILM)to the GCL boundaries), ganglion cell
layer (GCL) + (between RNFL to the inner nuclear layer boundaries), GCL++ (between ILM to the inner nuclear layer boundaries), and retinal thickness (from the ILM to the retinal pigment epithelium boundaries).
Hafidi, "Peripherin-like immunoreactivity in type II spiral ganglion cell
body and projections," Brain Research, vol.
KEY WORDS: Gut Motility; Histology; Ganglion Cell
; Smooth Muscle