Other examples of neoplastic counterparts to normal precursors include chronic lymphocytic leukemia/small lymphocytic lymphoma at the mature B-cell stage,
follicular center cell lymphoma at the activated B-cell stage, and multiple myeloma at the plasma cell stage.
In most reported cases, the spindle cell variant of diffuse large B-cell lymphoma is positive for the B-cell marker CD20 with coexpression of bcl-6 in a subset of reported cases, consistent with
follicular center cell derivation [12-14].
(7,8) Although originally interpreted to be of
follicular center cell origin, the lymphoma cells of MALT were later designated as "entrocyte-like" and currently are termed marginal zone cells.