The authors do not discard the possibility that cultural habits and socioeconomic conditions may also explain
familial aggregation. Publications show divergent findings regarding this issue.
Familial aggregation and excess maternal transmission of type 2 diabetes in Tunisia.
In India, nearly 75% of type-2 diabetics are reported to have first degree family history of diabetes, indicating a strong
familial aggregation. [29] However, we could not find any association with
familial aggregation in our study, because of the fact that family history of diabetes may not be noted down in the record.
Pachman, "
Familial aggregation of autoimmune disease in juvenile dermatomyositis," Pediatrics, vol.
Familial aggregation of Parkinson's disease [Letter].
Familial aggregation and segregation analysis studies of ARM have resulted in valuable information about the genetics of ARM.
The
familial aggregation pattern of the quantitative data from each measure in the battery was analyzed (Raskind et al., 2001).
Dropping both A and C from the model, resulted in a significantly worse fit for each measure ([[Delta][Chi]2.sup.2] = 37.24 (IQ), 22.06 (HITS), 19.03 (MAE), 8.90 (SD)) confirming that there was significant
familial aggregation. However, dropping only one of A [MATHEMATICAL EXPRESSION NOT REPRODUCIBLE IN ASCII] from the ACE model resulted in a nonsignificant [[Delta][Chi-square] indicating that either, or both, could be the cause of the familial correlation.
Letter:
Familial aggregation in nasopharyngeal carcinoma.
Camilla Krogh, of the Statens Serum Insti-tut, Copenhagen, Denmark, and colleagues examined the
familial aggregation of py-loric stenosis from monozygotic twins (derived from a single fertilized egg) to fourth-generation relatives in the population of Denmark.
Family history and genetic predisposition:
Familial aggregation and genetics factors are thought to play a role in the development of OSA.
Thus, both case-control and cohort studies strongly support the hypothesis that
familial aggregation and genetic susceptibility play an important role in the development of pancreatic cancer.