Identification of Factor XI
deficiency in Khuzestan buffalo population of Iran.
Molecular basis and bleeding manifestations of factor XI
deficiency in 11 Turkish families.
Factor XII is not an active participant towards haemostasis in vivo, but is activated in vitro by PTT reagent; hence its inclusion in the cascade as factor XII (in parenthesis), which activates factor XI
. (F = factor; I = fibrinogen; II = prothrombin; PTT = partial thromboplastin time; FDPs = fibrin/fibrinogen degradation products; PAI = plasminogen activator inhibitor; [[alpha].sub.2]-AP = alpha 2-antiplasmin inhibitor; tPA = tissue plasminogen activator.)
Deficiency--Resolving the Enigma?" Hematology/the Education Program of the American Society of Hematology.
Six genes (Vtgs 1 and 2, choriogenins 2 and 3, ER[alpha], and coagulation factor XI
) were upregulated in sheepshead minnows exposed to [E.sub.2], E[E.sub.2], DES, PNP, or MXC.
Drugs that diminish the activity of factor XI
might work to ease clotting without causing side effects--such as bleeding--that complicate current anticlotting drug therapy, Meijers says.
Total patients with inherited bleeding disorders according to diagnosis Bleeding Number of Sex Total disorder families M F Hemophilia A 63 69 -- 69 Hemophilia B 15 17 -- 17 vWD 11 12 13 25 Factor XI
9 4 6 10 deficiency Factor X 8 8 8 16 deficiency Factor VII 13 9 6 15 deficiency Factor V 6 7 8 15 deficiency Afibrino- 1 1 1 genemia Total 126 126 42 168 Bleeding Severity Age range disorder (years) severe moderate mild Hemophilia A 46 17 6 1/2-24 Hemophilia B 6 8 3 2-17 vWD -- -- -- 5-50 Factor XI
4 3 3 15-40 deficiency Factor X 4 2 10 1/2-35 deficiency Factor VII 3 -- 12 24-50 deficiency Factor V 2 3 10 5-30 deficiency Afibrino- 1 -- -- 1 genemia Total 66 33 44
Until a genetic abnormality is established, evaluation of factor VIII and possibly factor XI
coagulant levels may be useful in patients in whom no other abnormalities are detected.
These assays include VisuLize Factor VIII Antigen ELISA Kit, VisuLize Factor IX Antigen ELISA Kit, VisuLize Factor XI
Antigen ELISA Kit and VisuLize TAFI Antigen ELISA Kit.
The presence of tissue factor pathway inhibitor rapidly dampens the initial burst of thrombin, but the presence of sufficient thrombin engages a positive feedback loop, with activation of factor XI
, which helps to generate tenase (consisting of calcium, phospholipid, and activated factors IX and VIII), leading to more prothrombinase formation.
rose in all three groups including the saline group but was not statistically significant (p=0.275).
specific technical requirements: (a) ce marking of the instrument; b) connection to existing laboratory pre-analytical chain (roche model mpa: rd / modular analytics standard b); c) reagent panel with ce marking "in a-range" for the following analyzes; - tca (activated partial thromboplastin time), - tp (prothrombin time), tt (thrombin time), - fibrinogen, - d-dimers, - factor xii, - factor xi
, - factor ix, - factor viii, - von wilebrand antigen, - von willebrand activity, - factor ii, - v factor, - factor vii, - x factor, - antithrombin, - protein c, - protein s, - apcr (activated protein c resistance).