The interpolation results are typical, while the poor extrapolation
results shown by the bottom subplots are not surprising; empirical models cannot extrapolate.
The medical sciences community and drug regulatory authorities around the world have not yet come to a consensus on the extrapolation
of biosimilar indications.
Despite this theoretical disagreement, I have no quarrel with most of Schmeink's observations on the social influence of new biotechnologies, and on how science fictional extrapolation
allows us to comprehend this.
from this paper are aided by a particularly clear presentation of the epidemiological and diagnostic costs and factors used in the models.
The overall thrust of the extrapolation
issue was that if biosimilarity to Remicade was proven by a range of preclinical and clinical testing, and if safety and efficacy similar to Remicade was shown in trials that enrolled only patients with rheumatoid arthritis or ankylosing spondylitis, then the safety and efficacy previously proven for Remicade for the other indications could be reasonably extrapolated to apply to CT-P13 also, even though CT-P13 was never tested on patients with those conditions.
Doesn't that change the basic extrapolation
on which it was founded?"
Across the Boundaries: Extrapolation
in Biology and Social Science.
Meanwhile, beware of pseudo-scientific extrapolations
. Some of us recall during the 1970s when many of the same leftist and establishment organs were trumpeting the dangers of an imminent new ice age (based on minimally cooler Earth temperatures between 1940 and 1970).
Evolution is based on the illogical extrapolations
of small changes within a species (natural selection or the science of genetics), and invalid assumptions and contradictory evidence for the long time periods, used to justify not being able to observe the necessary fossil mutations.
In a single GPC/SEC experiment, this system can provide absolute molecular weight without the column calibration, extrapolations
or corrections required by other techniques, molecular size (to less than 1 nm) and intrinsic viscosity, as well as information on structure, conformation, branching, aggregation and copolymer composition, according to the manufacturer.
The ISO standard requires longer-term extrapolations
2 where linear fits for different subgroups of points for volumes in the range [V.sub.max]/V = 1 to 27 give [[tau].sub.n] extrapolations
within 0.5 s of the initial input value 886 s.