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Related to estimated creatinine clearance: Cockcroft-Gault formula


The process of settling transactions. Most exchanges have one or more clearing houses, which are charged with matching orders together, ensuring that deliveries are made to the correct parties, and collecting margin money. Because so many trades take place on an exchange in a given day, clearing houses exist to process what each party owes or is owed in a central location so the fewest securities actually change hands. For example, suppose that a broker-dealer buys 1000 shares of a security and then, in a completely separate transaction, sells 700 of the same shares. At the end of the trading day, the clearing house would determine that the broker-dealer must only buy 300 shares as the other 700 belong to another party. Clearing houses receive a clearing fee in exchange for clearance services.
Farlex Financial Dictionary. © 2012 Farlex, Inc. All Rights Reserved


Clearance is the first half of the process that completes your order to buy or sell a security. During clearance, the details on both sides of the transaction are compared electronically to ensure that the order to buy and the order to sell correspond.

For example, in a stock transaction, the Committee on Uniform Securities Identification Procedures (CUSIP) number, the number of shares, and the price per share must match.

Next, transactions within each broker-dealer are netted down, or offset, by matching its clients' buy orders against sell orders from others of its clients or among a group of affiliated firms. Their records are then updated to reflect the new ownership and account balances.

Any unmatched orders are forwarded to the National Securities Clearing Corporation (NSCC), which instructs selling broker-dealers to provide the relevant securities and the buying broker-dealer to send the cash.

Dictionary of Financial Terms. Copyright © 2008 Lightbulb Press, Inc. All Rights Reserved.
References in periodicals archive ?
We first compared the distribution of demographic and lifestyle characteristics, bone and blood lead levels, and uric acid and renal function (serum creatinine and estimated creatinine clearance) by genotype (ALAD 1-2/2-2 vs.
None was judged to be acceptable by the authors of that paper, who suggested that drug levels be used instead of estimated creatinine clearance, to adjust therapy in elderly patients [9].
Mean estimated creatinine clearance by Cockcroft Gault CrCl equation was 105.55+17.06 (ml/min); 88.66+14.33 (ml/min) by Cockcroft Gault GFR equation; and 92.66+13.87 (ml/min) by MDRD formula.
The authors proposed the following general model to estimate vancomycin clearance (Vclear): Vclear = 1.08 x estimated creatinine clearance. The equation for distribution volume (DV) was: DV = 0.98 x weight (kg).
After completing the aminoglycoside component of MDR TB treatment, patients could be switched to tenofovir provided the estimated creatinine clearance is >50 ml/min.
The three groups were matched for estimated creatinine clearance (CrCI) and had comparable gender, age, and time since transplantation.

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