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Related to estimated creatinine clearance: Cockcroft-Gault formula


The process of settling transactions. Most exchanges have one or more clearing houses, which are charged with matching orders together, ensuring that deliveries are made to the correct parties, and collecting margin money. Because so many trades take place on an exchange in a given day, clearing houses exist to process what each party owes or is owed in a central location so the fewest securities actually change hands. For example, suppose that a broker-dealer buys 1000 shares of a security and then, in a completely separate transaction, sells 700 of the same shares. At the end of the trading day, the clearing house would determine that the broker-dealer must only buy 300 shares as the other 700 belong to another party. Clearing houses receive a clearing fee in exchange for clearance services.


Clearance is the first half of the process that completes your order to buy or sell a security. During clearance, the details on both sides of the transaction are compared electronically to ensure that the order to buy and the order to sell correspond.

For example, in a stock transaction, the Committee on Uniform Securities Identification Procedures (CUSIP) number, the number of shares, and the price per share must match.

Next, transactions within each broker-dealer are netted down, or offset, by matching its clients' buy orders against sell orders from others of its clients or among a group of affiliated firms. Their records are then updated to reflect the new ownership and account balances.

Any unmatched orders are forwarded to the National Securities Clearing Corporation (NSCC), which instructs selling broker-dealers to provide the relevant securities and the buying broker-dealer to send the cash.

References in periodicals archive ?
Renal function needs to be measured prior to commencement and monitored in clients using PrEP by measuring serum creatinine and calculating the estimated creatinine clearance.
Table 3 shows the relationship of serum creatinine or estimated creatinine clearance with bone lead level with and without an interaction term for bone lead and genotype and before (n = 709) and after (n = 670, because of 39 missing data in body mass index and alcohol consumption) adjusting for other potential confounders identified in our previous investigation (19).
Measured versus estimated creatinine clearance in a high-functioning elderly sample: MacArthur Foundation study of successful aging.
Our first case highlights another important point: that it is critically important to calculate the estimated creatinine clearance in patients before starting tenofovir, and if it is <50 ml/min, tenofovir should not be used.
Small increases in serum creatinine (a value used to estimate kidney function) with resulting decreases in estimated creatinine clearance (by Cockroft-Gault) were observed in this study.
A cutoff of 80 mL/min was selected for normal estimated creatinine clearance (15).

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