Patients with AD have severe episodic memory
impairment due to damage to the storage of information, which is caused by the atrophy of the hippocampus and medial temporal lobe.
"We're interested in episodic memory
- and episodic memory
replay - because it declines in Alzheimer's disease, and in aging in general."
Based on the findings from phase 2a, the company has initiated a 6-month phase 2b clinical study (REVERSE-SD) designed to evaluate neflamapimod's activity in reversing synaptic dysfunction, as assessed by tests of episodic memory
in patients with mild Alzheimer's disease.
During the test, the results indicated an enhancement of episodic memory
performance for semantically related word pairs compared to semantically unrelated ones in both healthy controls and schizophrenia patients.
The results obtained in this study, although they refer to a specific section of a much wider problem (memory problem in the AD), are consistent with cross-sectional studies, where it is reported that the episodic memory
impairment of mild-AD patients is characterized by encoding deficit and low retrieval performance compared to HOA .
As a result of using those two measurements, the researchers observed brain activity and any changes in three areas: the DLPFC that controls planning, decision-making, and inhibition; the cerebellum that plays a major role in motor control and balance; and the hippocampus, the centre of spatial and episodic memory
Key words: primary insomnia, cognitive function, episodic memory
, influencing factors
The experience of recalling a past event and "reliving" that experience is the basis of episodic memory
To test whether the timing of estrogen therapy affected the primary cognitive endpoint of verbal episodic memory
, the researchers conducted ELITE (Early vs.
The main ELITE trial tested the effect of the timing of estradiol, compared with placebo, on the progression of subclinical atherosclerosis, whereas the ELITE-Cog trial assessed the effects of the timing of estradiol on a composite test of verbal episodic memory
The episodic memory
tested in the rodents was the memory of an aversive experience: a mild foot shock received upon entering in a new place.
Those participants who took regular moderate to high-intensity exercise (for example, jogging and/or aerobics) showed less decline in their processing speed and episodic memory
over follow-up than participants who took only light exercise (for example, walking).