aspirin by the patient, mostly having cardiocerebrovascular disease or combining cardiopulmonary disease, is a relative contraindication to undertake gastroscopy under light or conscious sedation.
Beginning next month, the United States Pharmacopeia (USP), a nonprofit organization that sets quality standards for drugs and dietary supplements, will require delayed-release (i.e., enteric-coated
) garlic supplements to release at least 80% of their claimed allicin potential in order to earn the USP symbol on their labels.
Ask your pharmacist to provide a list of other drugs which, although neither sustained-release nor enteric-coated
, should not be crushed because they may irritate the oral mucosa, are extremely bitter, or contain dyes or substances that stain the teeth or mucosa.
Also, toxic doses of enteric-coated
aspirin can result because patients often take larger doses, assuming that the coated version is "safer."
"These observations question the value of seeking to diagnose aspirin resistance with single point-of-care diagnostic approaches and support the finding of inconsistent platelet inhibition following enteric-coated
preparations of aspirin," they concluded (Circulation 2012 [doi: 10.1161/CIRCULATIONAHA.112.117283]).
It is important to note that the product was enteric-coated
to avoid destruction by the acidic pH of the stomach.
Patients using enteric-coated
aspirin also were more likely than others to show resistance.
In a 2 1/2-year study of 517 people who had been cured of colorectal cancer, a new polyp was found in 17 percent of those taking a daily enteric-coated
aspirin (325 mg), compared to 27 percent of those taking a placebo.
Kline, Ph.D., of the University of Missouri-Columbia, and his associates, patients were given enteric-coated
capsules that contained 187 mg peppermint oil or a placebo (arachis oil).
(Do not do this with a slow-release or enteric-coated
Previously, only dry ingredients in tablet form could be enteric-coated
Pentoxyphylline (Trental), 400mg TID with meals, along with decaffeination of diet, may be beneficial, especially if combined with an enteric-coated
ASA 325mg tablet twice a week and a graded walking program to improve exercise tolerance.