Transmissible spongiform encephalopathy
(TSEs) or prion diseases are a group of invariably fatal conditions that affect central nervous system (CNS) and more specifically the brain and spinal cord.
Consciousness impairment may vary from confusion, somnolence and lethargy to encephalopathy
The Task Force on Neonatal Encephalopathy
published guidelines in 2014, according to which "If a comprehensive etiologic evaluation is not possible, the term hypoxic-ischaemic encephalopathy
should best be replaced by neonatal encephalopathy
because neither hypoxia nor ischaemia can be assumed to have been the unique initiating causal mechanism".8 Appropriate evaluation of HIE provides the family a chance of a correct diagnosis, proper genetic counseling and future reproductive options.
The RBANS has been used as an alternative test to the PHES (Pearson Education, Inc., San Antonio, TX, USA) and has been recommended for the diagnosis of MHE by the International Society for the Study of Hepatic Encephalopathy
and Nitrogen Metabolism (25).
Knopp's preclinical Kv7 platform is directed to small molecule treatments for neonatal epileptic encephalopathy
, other rare epilepsies, tinnitus, and neuropathic pain.
A recent meta-analysis of 7 large randomised controlled trials has demonstrated that TH improves survival (without increasing disability) and neurodevelopmental outcome at 18 months of age in neonates with moderate or severe encephalopathy
.  When compared with standard supportive care, there is a significant reduction in death (risk ratio (RR) 0.75, 95% confidence interval (CI) 0.63-0.88), major disability (RR 0.68, 95% CI 0.56-0.83), cerebral palsy (RR 0.62, 95% CI 0.49-0.78), developmental delay (RR 0.66, 95% CI 0.52-0.82) and blindness (RR 0.56, 95% CI 0.33-0.94) at 18 months of age.
First, potential causes of encephalopathy
such as infection, toxins, neoplasia, vasculitic syndromes, metabolic conditions and electrolyte disorders should be excluded.
Dr Farooqi explains that diabetic encephalopathy
is a condition that predominantly effects the elderly and that once someone contracts the condition, it is difficult to treat.
Embolization of large spontaneous portosystemic shunts for refractory hepatic encephalopathy
: a multicenter survey on safety and efficacy.
Keywords: Ischaemic encephalopathy
, Therapeutic hypothermia.
Additionally, Kannalife has developed its own patented molecules led by KLS-13019 and was awarded US Patent #9,611,213 "Functionalized 1,3-benzene diols and their method of use for the treatment of hepatic encephalopathy
." KLS-13019 is 50-fold more potent as a neuroprotectant and >400-fold safer than cannabidiol (CBD).
Conclusion: Patients suffering from advanced cirrhosis appeared to have lower serum zinc levels.In patients suffering from viral cirrhosis having hepatic encephalopathy
, zinc supplementation might improve clinical outcome.