Influence of MRP2 inhibitor probenecid on drug absorption
Alcohol abuse is another potential cause of reduced drug absorption
and it could have contributed in cases and controls to reduce intestinal drug absorption
and produce low serum concentrations .
12~ provide good evidence that there is no significant difference in gastric emptying between young and elderly volunteers and hence that age does not alter this rate-limiting step in drug absorption
The PK study will determine the metabolism of the drug and the effect of food on drug absorption
in healthy volunteers.
com)-- International Stem Cell Corporation (OTC Bulletin Board: ISCO), the first company to perfect a method of creating human "parthenogenetic" stem cells from unfertilized eggs, announced the results of a second set of experiments confirming that its lab-grown corneal tissue closely mimics the drug absorption
and drug metabolism characteristics found in normal corneal tissue.
The authors conclude: "The findings of this study suggest that an increased Tamiflu dosage is unlikely to be necessary in such cases based on either insufficient drug absorption
or altered distribution pharmacokinetics.
They focus on providing an comprehensive scientific basis as they cover drug absorption
and distribution, drug elimination, pharmacokinetics, drug action and interaction, variability in response, intravenous and inhaled anesthetic agents, local anesthetics, drugs that act on the neuromuscular junction, analgesics, pre-medication and anti-emetic drugs, the effects of drugs on the autonomic nervous system, antihypertensives, antiarrhythmic and antianginal drugs, antiplatelet and anticoagulant drugs, fibrinolytic agents, corticosteroids and hypoglycemic agents.
Improved onset of action for orally administered products where drug absorption
into the bloodstream is limited by dissolution rate.
However, Procter & Gamble asserts that olestra does not interfere with drug absorption
, he says.
The collaboration is aimed at studying how the use of MAM can provide additional insight and greater accuracy with regards to prediction of complex drug absorption
characteristics, and to facilitate drug and generic product development by decreasing the regulatory burden through adequate modeling approaches.