The little dose
is turning on some kind of protective mechanisms so that when a big dose
comes along, it's not as damaging," says radiation biologist J.
At 16 weeks in the overall group, when the 200 mg dose
of Reverset was used as add-on therapy in either an optimized or non-optimized regimen, patients who received Reverset achieved:
PA-457, the first-in-class maturation inhibitor, exhibits antiviral activity following a single oral dose
in HIV-1-infected patients.
The researchers affirm that there were no differences in efficacy among the three treatment groups; moreover, within the limits set by the study, the single dose
of levonorgestrel was at least as effective as the split dose
For a given degree of tumor-cell killing, the delivery of multiple small doses
of radiation (fractionation) carries a lower risk of late complications than does the delivery of a single large dose
Grades 1-6 and 8-12: 1 dose
, must be on or after 1st birthday.
In general, higher drug doses
result in a greater opportunity for therapeutic benefit as long as the dose
does not cause toxicity," said CytRx Chief Scientific Officer Jack Barber, Ph.
Some of the women received a dose
of nevirapine as they entered labor.
Later it was learned from the same study that even the single dose
sometimes selects for resistance mutations in the mother's HIV--a serious problem because it could make her treatment more difficult in the future.
5%) had experienced salivary gland dysfunction after a median dose
of 100 mCi.
The initial Phase 2b bevirimat tablet dose
of 400 mg was chosen based on an earlier clinical bioavailability study indicating that the tablet had approximately 60% of the oral bioavailability of an oral solution formulation.
We believe that the committee's recommended reference dose