The little
dose is turning on some kind of protective mechanisms so that when a big
dose comes along, it's not as damaging," says radiation biologist J.
At 16 weeks in the overall group, when the 200 mg
dose of Reverset was used as add-on therapy in either an optimized or non-optimized regimen, patients who received Reverset achieved:
PA-457, the first-in-class maturation inhibitor, exhibits antiviral activity following a single oral
dose in HIV-1-infected patients.
The researchers affirm that there were no differences in efficacy among the three treatment groups; moreover, within the limits set by the study, the single
dose of levonorgestrel was at least as effective as the split
dose.
For a given degree of tumor-cell killing, the delivery of multiple small
doses of radiation (fractionation) carries a lower risk of late complications than does the delivery of a single large
dose.
Grades 1-6 and 8-12: 1
dose, must be on or after 1st birthday.
In general, higher drug
doses result in a greater opportunity for therapeutic benefit as long as the
dose does not cause toxicity," said CytRx Chief Scientific Officer Jack Barber, Ph.
Some of the women received a
dose of nevirapine as they entered labor.
Later it was learned from the same study that even the single
dose sometimes selects for resistance mutations in the mother's HIV--a serious problem because it could make her treatment more difficult in the future.
5%) had experienced salivary gland dysfunction after a median
dose of 100 mCi.
The initial Phase 2b bevirimat tablet
dose of 400 mg was chosen based on an earlier clinical bioavailability study indicating that the tablet had approximately 60% of the oral bioavailability of an oral solution formulation.
We believe that the committee's recommended reference
dose of 0.
