Estrogen receptor-[alpha] mediates the detrimental effects of neonatal diethylstilbestrol
(DES) exposure in the murine reproductive tract.
Low dose effects of in utero exposure to bisphenol A and diethylstilbestrol
on female mouse reproduction.
Treatment Costs in Advanced Prostate Cancer Lifetime Costs (in 1998 dollars) Diethylstilbestrol
$ 3,600 Orchiectomy $ 7,000 Nonsteroidal antiandrogen (nilutamide or bicalutamide) $16,100 Nonsteroidal antiandrogen plus orchiectomy $20,700 Luteinizing hormone--releasing hormone agonist (goserelin or ketoconazole) $27,000 Nonsteroidal antiandrogen plus luteinizing hormone--releasing hormone agonist $40,300 Source: J.
Briefly, participants from three cohorts originally identified for study during the 1950s-1970s--the Diethylstilbestrol
Adenosis Project (DESAD; Labarthe et al.
Effects of neonatal diethylstilbestrol
(DES) exposure on morphology and growth patterns of endometrial epithelial cells in CD-1 mice.
(The typical American diet derives about 38 percent of its calories from fat.) Half the animals in each dietary group also received diethylstilbestrol
(DES), a drug that gained notoriety when researchers linked it with reproductive cancers in the daughters of women who had taken it during pregnancy.
Down-regulation of Wnt7a is a known factor in the reproductive deficits found in mice exposed to diethylstilbestrol
(DES), a synthetic estrogen once used to supplement estrogen levels in pregnant women.
Perinatal exposure to high concentrations of the potent synthetic estrogen diethylstilbestrol
(DES) induces abnormal development of the female reproductive tract via a mechanism that acts through the down-regulation of Wnt7a (wingless-type MMTV integration site family, member 7A).
For example, the genital cancers that were identified in young women, on average 19 years after their prenatal exposure to the drug diethylstilbestrol
, were seen in females who had appeared to be completely normal until that time (Herbst et al.
Low doses of bisphenol A and diethylstilbestrol
impair [Ca.sup.2+] signals in pancreatic [alpha]-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans.
For ER competition studies, rat uterine tissue was homogenized in 10 mM Tris, 1.5 mM EDTA, and 0.1 mM dithiothreitol, pH 7.4 at 22[degrees]C, and uterine nuclear suspensions were incubated at 37[degrees]C for 30 min in the presence of 10 nM [[sup.3]H]estradiol [+ or -] 0.01-10 [micro]M LTX-diol or diethylstilbestrol
(DES) under conditions that measure only [[sup.3]H]estradiol binding to ERs (Markaverich et al.
(2) This cancer usually has been reported in women with past medical history of diethylstilbestrol
exposure (DES), but there must be some other unknown etiology for that.