Estrogen receptor-a mediates the detrimental effects of neonatal diethylstilbestrol
(DES) exposure in the murine reproductive tract.
(DES), a highly potent, orally available synthetic estrogen, is perhaps the most studied among the class of exogenous estrogens since being strongly associated with vaginal adenocarcinoma and abnormalities of the uterus and cervix in young women who were exposed via pharmacological use by their mothers during pregnancy (Herbst et al.
In the preclinical monkey study, Capesaris and diethylstilbestrol
(DES), an orally available nonselective estrogen agent which has been used for ADT, each reduced serum testosterone to castrate levels (<50 ng/dL).
In utero exposure to diethylstilbestrol
(DES), maternal prepregnancy or gestational diabetes, and having been born from a monozygotic multiple birth were most strongly associated with early-onset fibroids.
These chemicals included diethylstilbestrol
, two thalates and bisphenol A (BPA).
EDCs noted in the review include environmental estrogens, or estrogen mimics, most notably BPA, which is a synthetic monomer used in the production of polycarbonate plastics and epoxy resins, as well as poly-chlorinated biphenyls, diethylstilbestrol
, dioxins, and phthalates.
Gourmeds currently is available to prescribers for four commonly prescribed pet mediations, including Cisapride, Metronidazole, Diethylstilbestrol
exposure, and family history are potential risk factors for fibroids, according to study results presented at an international conference on uterine leiomyoma research, sponsored by the National Institutes of Health.
He first became interested in livestock hormones in the early 1970s, when he learned that farmers were giving the synthetic hormone diethylstilbestrol
(DES) to chickens and cattle.
We also know that bisphenol A is similar in chemical structure to diethylstilbestrol
, a synthetic estrogen that has been linked to the development of vaginal cancer and other toxicities in the daughters of women who took the drug during the '50s and '60s to prevent miscarriage.
METHODS: Female CD-1 mice that were exposed to BPA at 0, 25 ng, 250 ng, or 25 [micro]g/kg body weight (BW)/day or diethylstilbestrol
(DES) at 10 ng/kg BW/day (positive control) from gestational day 8 through day 16 of lactation were continuously housed with proven breeder males for 32 weeks starting at 2 months of age.
Washington, May 29 (ANI): Exposure in the womb to chemicals like Bisphenol-A (BPA) and Diethylstilbestrol
(DES) can increase an offspring's risk of breast cancer, according to a new study.