Keywords: index, cache, delta cell
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In accordance with the observed delta cell
hyperplasia, the SST stimulation index for the glucose-stimulated SST secretion in isolated PI was increasing with age of GK rats and was significantly higher when compared to the age-matched Wistar rats (41- and 56-week-old) (Figure 10(e)).
"The really exciting finding is that in the laboratory at least, we have been able to reverse the changes - turn the delta cells
back to beta cells - if we restore the environment to normal, or if we treat the cells with chemicals that restore the regulator genes and the patterns of RNA messages made to normal.
Gamma delta cells
have the potential to be the next generation of immunotherapy treatments, as they show promise to be highly potent and target-specific.
The team's discovery of a protein called Butyrophilin 3A1 shows how it binds to microbial antigens and hence activates human gamma delta cells
. These cells are then able to coordinate an immune response to clear the infection caused by invading microbes.
Expression profiling analyses in the mouse demonstrated high PPAR[beta]/[delta] expression in the cytoplasm of delta cells
of the islet of Langerhans, suggesting a potential role for the receptor in the regulation of glucose metabolism .