Although considered a rare event with controversial pathophysiological mechanisms, three hypotheses have been suggested: an immune humoral response, a delayed hypersensitivity reaction
and altered hepatic metabolism including acetylation and hydroxylation with secondary toxic metabolite production.
In lower concentrations, eugenol can act as a contact allergen evoking a localized delayed hypersensitivity reaction
This is a delayed hypersensitivity reaction
. Type I is the true latex allergy and is an immediate response to latex exposure and with each exposure can increase in severity, even to anaphylaxis.
To determine whether delayed hypersensitivity reaction
to foods might be a factor in the development of chronic diarrhea in children, researchers measured IgG antibodies and prescribed an elimination diet to children in four different groups.
Delayed hypersensitivity reaction
to topical aminoglycosides in patients undergoing middle ear surgery.