C and D, Clear cell papillary RCC (CCPRCC) example shows a predominantly tubular architecture with linearly arranged, apically oriented, low-grade nuclei; CA-IX expression is strong and diffuse in a basolateral ("cuplike
") membranous pattern (D).
Alternatively, the section may reveal the cuplike shape of the cell (Fig.
The cuplike shape of the label within the median eye (Fig.
Acute myeloid leukemia with fms-related tyrosine kinase (FLT3) internal tandem duplication and NPM1 mutation is associated with cuplike
nuclei, which can be confused with the folded nuclei seen in APL.
calyces containing U-shaped guts and ringed by tentacles are borne on stalks arising from prostrate stolons.
Unlike the 9-foot 440-pound giant squid Architeuthis dux that washed onto a Massachusetts beach years earlier, this new squid has hooks instead of cuplike
suckers on its arms, says Clyde Roper, a zoologist with the Smithsonian Institution's National Museum of Natural History in Washington, D.C.
Interestingly, however, CAIX staining in CCPRCC is characteristically absent from the apical cell membrane, which imparts a distinctive cuplike
pattern that may be useful diagnostically.
CAIX commonly shows an absence of staining along the luminal surface, yielding a "cuplike
" staining pattern.
However, it should be noted that many [CD34.sup.-], HLA-[DR.sup.-] acute myeloid leukemias will not have an associated PML-RARA1, instead representing clinically and molecularly distinct entities, such as the so-called acute myeloid leukemia with cuplike
(16-23) Kussick et al (24) linked FLT3/ ITD mutations with blasts having invaginated (cuplike
) nuclei among nonpromyelocytic/nonmonocytic AMLs.
The cartilage-bone junction at the level of the growth plates was curved, with the concavity facing the cartilage; periosteal ossification projected beyond the metaphyseal margins in the form of bony spurs causing a cuplike