The median cumulative exposure
level and duration of exposure in exposed workers was 59 mg/[m.sup.3]-years (75th percentile: 136 mg/[m.sup.3]-years; 95th percentile: 491 mg/[m.sup.3]-years) and 17 years, respectively.
In contrast, 86% of 206 patients in the lowest-risk group (low cumulative exposure
to PSA and low Gleason score) were alive at 5 years, and 42% were alive at 15 years.
In a review of 481 patients seen from 1983 to 2004 at a single center, risk groups defined by low or high cumulative exposure
to PSA (lower or higher than 60 ng/mL) and low or high Gleason score (57 or 8-10) were significantly associated with the duration between prostate cancer diagnosis and death or loss of follow-up.
We used the midpoint of the range of each exposure category as a specific estimate of the cumulative exposure
for each RR.
We estimated associations with cumulative exposure
to PFOA, which was calculated by summing estimated yearly serum concentrations during follow-up and modeled as a time-dependent variable in Cox regression.
"We should at least consider putting into place a system of prospectively documenting the imaging tests and procedures that each patient undergoes and estimating his or her cumulative exposure
to low-dose ionizing radiation."
at 1, 3, and 6 months of age also was associated with language, speech, and general neurodevelopmental delays, Dr.
In his letter, Morfeld states that "an adjustment of cumulative exposure
by total duration of employment should not be confused with an approach adjusting for the healthy worker survivor bias." However, our assessment (Garshick et al.
Women exposed to moderate to high levels for a combination of years and intensity of exposure had a significant dose response so that the risks for developing breast cancer increased as the cumulative exposure
levels increased, according to Reynolds.
CONCLUSIONS: Lung cancer mortality in trucking industry workers increased in association with cumulative exposure
to EC after adjusting for negative confounding by employment duration.
The findings revealed that cumulative exposure
to respirable coalmine dust was a highly significant predictor of emphysema severity after accounting for cigarette smoking, age at death, and race.
Pleural abnormalities also were more strongly associated with cumulative exposure
estimated to have been acquired over many years than with higher intermittent peak exposures.