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Related to creatinine clearance: Creatinine clearance test, Serum creatinine


The process of settling transactions. Most exchanges have one or more clearing houses, which are charged with matching orders together, ensuring that deliveries are made to the correct parties, and collecting margin money. Because so many trades take place on an exchange in a given day, clearing houses exist to process what each party owes or is owed in a central location so the fewest securities actually change hands. For example, suppose that a broker-dealer buys 1000 shares of a security and then, in a completely separate transaction, sells 700 of the same shares. At the end of the trading day, the clearing house would determine that the broker-dealer must only buy 300 shares as the other 700 belong to another party. Clearing houses receive a clearing fee in exchange for clearance services.


Clearance is the first half of the process that completes your order to buy or sell a security. During clearance, the details on both sides of the transaction are compared electronically to ensure that the order to buy and the order to sell correspond.

For example, in a stock transaction, the Committee on Uniform Securities Identification Procedures (CUSIP) number, the number of shares, and the price per share must match.

Next, transactions within each broker-dealer are netted down, or offset, by matching its clients' buy orders against sell orders from others of its clients or among a group of affiliated firms. Their records are then updated to reflect the new ownership and account balances.

Any unmatched orders are forwarded to the National Securities Clearing Corporation (NSCC), which instructs selling broker-dealers to provide the relevant securities and the buying broker-dealer to send the cash.

References in periodicals archive ?
Cockcroft DW, Gault MH Prediction of creatinine clearance from serum creatinine.
However, because we found cadmium-associated effects on NAG and protein HC even in never-smokers, and there was no effect of smoking on creatinine clearance or GFR, this is unlikely.
Both fluids also transiently increased creatinine clearance and achieved a sustained decrease in urinary sodium excretion and urine osmolarity.
There were no significant changes in urine output or creatinine clearance from baseline when comparing AVP to control animals.
A 4-hr urine collection after oral administration of 10 mg/kg DMSA was also obtained to measure DMSA-chelatable lead and creatinine clearance (787 participants completed this collection).
To test this hypothesis, we examined the relationship between total plasma PUFA levels and change in creatinine clearance over a 3-year follow-up in the older participants of the InCHIANTI study, a population-based epidemiology study conducted in Tuscany, Italy.
Creatinine clearance was estimated on the basis of the serum creatinine concentration according to the method of Cockcroft and Gault (18).
In a Phase 3 complicated intra-abdominal infections (cIAI) trial, clinical cure rates were lower in a subgroup of patients with baseline creatinine clearance (CrCL) of 30 to 50 mL/min compared to those with CrCL greater than 50 mL/min.
The last may be calculated by the Cockcroft-Gault or modification of diet in renal disease (MDRD) formula or by measuring the 24-hour urinary creatinine clearance.
label, SAVAYSA should not be used in NVAF patients with creatinine clearance (CrCL) levels greater than 95 mL/min because in that population there is an increased risk of ischemic stroke compared to warfarin.
The prescribing information includes a warning about decreased efficacy in patients with renal impairment (a baseline creatinine clearance of 30-50 mL/min or less, and the recommendation to monitor creatinine clearance "at least daily in patients with changing renal function," and to adjust dose accordingly.
Baseline urinalysis and calculated creatinine clearance or eGFR are especially important in blacks with HIV and people with advanced HIV infection or comorbid conditions because these groups run a higher risk of nephropathy.

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