PASH like changes is also incidentally detected with other breast lesions such as fibrocystic disease, fibroadenomas, columnar cell
lesions, lobular neoplasia and in situ and invasive ductal carcinoma.
Fibrocystic changes comprised the largest number of the benign breast cases, closely followed by columnar cell
Ratios of basal cells to columnar cells
were determined from counts made of cross-sectioned glands at the light microscopic level (epoxy resin sections, 50X).
Elias et al found that the relative risk of finding mild to moderate dysplasia in Papanicolaou smears containing endocervical columnar cells
lesions of the breast: the missing link in breast cancer progression?
2%), fibrocystic disease with columnar cell
change associated with usual ductal hyperplasia in 8 cases (21%), followed by sclerosing adenosis with UDH in 2 cases (5.
95) The columnar variant may contain a predominant population of tall, columnar cells
and a second component of polygonal cells with pale cytoplasm, which may give the false impression of a MEC layer.
Recognition of the intraluminal eosinophilic (or rarely basophilic) basement membrane material surrounded by flattened myoepithelial cells (as opposed to polarized columnar cells
in cribriform DCIS) is crucial to avoid erroneous diagnosis (Figure 3, C and D).
Apical cytoplasmic snouts, similar to those seen in columnar cell
change, are frequently present (Figure 3, F).
The columnar cell
variant of PTC was first reported by Evans in 1986.
She underwent stereotactic needle core biopsy of the calcifications, which showed columnar cell
change with microcalcifications and ALH, as shown in Figure 1.
Specific microscopic features were recorded, including growth pattern and nuclear grade of LCIS, the number and percentage of cores containing LCIS, the presence of a coexisting columnar cell
lesion, and the presence and location of calcifications in the biopsy.