Collagenous colitis more commonly affects women older than seventy years and presents with chronic watery diarrhea, with or without abdominal pain, and weight loss.
Collagenous colitis has been associated with multiple medications as well as autoimmune disorders such as thyroid diseases, rheumatoid and psoriatic arthritis, systemic lupus erythematosus, and Sjogren syndrome.
Theories regarding the pathogenesis of collagenous gastritis and collagenous sprue suggest that the evolution of these diseases is similar to that of collagenous colitis, but there are few data to support or refute this.
The pathogenesis of collagenous colitis has been studied most extensively of all the collagenous gastroenteritides, although the exact mechanism of its pathogenesis is still unknown.
Nonsteroidal anti-inflammatory drugs, usually used for greater than 5 years, are among the most common drugs associated with collagenous colitis.
The etiology of the diarrhea in collagenous colitis is also not well understood.
10) Collagenous colitis and collagenous gastritis also share other histologic features besides the defining bandlike linear deposition of extracellular matrix: they both show lack of extension of the linear matrix deposition forming the thickened collagen plate along the crypts, lymphocytic infiltrate of the overlying epithelium is present in both, and the surface epithelium in both sites may flatten or become cuboidal.
Collageneous gastroduodenitis on collagenous colitis.
Collagenous gastrobulbitis and collagenous colitis.
Small intestine in lymphocytic and collagenous colitis.