: histologic, morphometric, immunohistochemical and ultrastructural studies.
Interventions for treating collagenous colitis
. Cochrane Database Syst Rev.
This patient had concomitant collagenous colitis
. C, Cholestyramine crystals are irregular in shape, opaque, and orange.
We found that despite the subtle inflammation in the mucosa of collagenous colitis
patients, not visible by the naked eye upon colonoscopy, soluble factors in the mucosa are sufficient to significantly enhance the production of IFN-[gamma], IL-17A, IL-6, IL-1[beta], IL-4, and IL-10 by peripheral [CD4.sup.+] T cells exposed to them in vitro.
Although we had no doubts about excluding a CD diagnosis in the two patients with Crohn disease and in the two with chronic liver disease, both collagenous colitis
(28) and psoriasis (29) have been reported to be associated with CD.
C, Collagenous colitis
may complicate longstanding idiopathic inflammatory bowel disease.
Colon biopsies may show increased IELs, subepithelial collagen thickening (Figure 7), and lamina propria chronic inflammation that can resemble lymphocytic or collagenous colitis
. (3, 5, 8, 11, 13, 16-19) Colonic crypt apoptoses have also been described.
(4,5) Microscopic colitis comprises 2 entities, namely collagenous colitis
(CC) and lymphocytic colitis (LC), which are indistinguishable clinically but are separated by histopathologic characteristics.
This can be particularly frustrating when trying to evaluate the surface epithelium for the changes of lymphocytic colitis (LC) or collagenous colitis
Confocal laser endomicroscopy has been shown to specifically detect lymphocytic and collagenous colitis
in the evaluation of chronic diarrhea, including observation of mononuclear infiltration in lymphocytic colitis and subepithelial collagenous bands in collagenous colitis
In patients with ongoing diarrhea and spruelike diseases refractory to gluten-free diet, collagenous colitis
and lymphocytic colitis need to be excluded, both of which may be patchy in distribution and sampling errors could occur, so random colon biopsies, including the right colon, may be warranted.
This set of disorders includes collagenous gastritis, collagenous sprue, and collagenous colitis
. A survey of the medical literature reveals associations between these entities in enough patients to support the notion that they must be related.