It is interesting that for each of the different modes of entry of C, H, N, O, P, and S, there is at least one cofactor
present that enables their incorporation into components of the metabolome (unpubl.
The Phase II clinical trial is a single arm, multicenter study to evaluate the safety and efficacy of treatment with CoFactor
plus 5-FU in advanced breast cancer patients who have failed anthracycline and taxane chemotherapies.
In addition to the clear effects of substrate and cofactor
identity and concentration on rubber biosynthesis, there are developmental and environmental effects to factor in as well.
are included in models  and  by adding the term
However, many of their cofactors
were based upon QI matrices.
vitamins, minerals, cofactors
, etc.) and monitor drug and additive compatibility, working with a homecare program to provide the solutions, supplies and equipment.
A limited mutagenesis study (manuscript in preparation for Nature Chemical Biology) in which evolutionarily-selected mutations located spatially close to the active site were swapped between SodA and SodM identified three residues that play a key role in determining cofactor
specificity, but these mutations are insufficient to fully explain the enzymes' differing metal specificities.
said the acquisition advances its expansion into RNA-based diagnostics and further solidifies its plans for the development and delivery of RNA-based tests for cancer and neurodegenerative disease.
Tetrahydrobiopterin is an essential cofactor
in the biosynthesis of catecholamines, serotonin and melatonin.
Comment: ALA is a cofactor
for mitochondrial respiratory enzymes, and improves mitochondrial function.
It also serves as an important cofactor
in the synthesis of epinephrine.
Editor's Note: While statin drugs are of benefit to millions of people at risk for cardiovascular events, their effect on coenzyme Q10, an important mitochondrial cofactor
, has not been well publicized in mainstream medical media.