Treatment with compounds inducing differentiation of 3T3-L1 preadipocytes leads to mitotic
clonal expansion prior to the expression of PPAR[gamma], a key adipogenic transcription factor.
Suppression of oncogenic signalling is necessary to prevent stimuli driving commitment to
clonal expansion and differentiation from antagonizing the long-term maintenance of stem cell properties in the SCN.
A third emerging application of tracking
clonal expansion is in the context of autoimmune diseases, where research is attempting to identify particular V - (D) - J recombinants associated with autoimmune diseases with the plan of monitoring their levels in response to therapeutic options.
Sin et al., "Sulforaphane inhibits mitotic
clonal expansion during adipogenesis through cell cycle arrest," Obesity, vol.
Hence, Stat3 status influenced survival of DNA-damaged KSCs, since the absence of Stat3 led to increased apoptosis of bulge region KSCs following treatment with DMBA ultimately leading to reduced number of mutated cells available for
clonal expansion during tumor promotion [25].
(2010) Antigen-specific
clonal expansion and cytolytic effector function of [CD8.sup.+]T lymphocytes depend on the transcription factor Bcl11b.
Hypermutation combined with
clonal expansion is an adaptive process known as affinity maturation (Berek & Ziegner, 1993).
This suggests that MCPyV is involved in
clonal expansion of the tumor.
Hampering of pyrimidine synthesis hinders T-cell
clonal expansion (3).
They review research into the
clonal expansion of a single, normal or mutated stem cell in order to bring new insights into both the biology of the gastrointestinal tract and tumorigenesis in the intestine.
T-cell receptor gene rearrangement studies may suggest the presence of
clonal expansion In some cases, however, these
clonal expansions do not constitute a lymphoma [2,3].
"In terms of lung cancer susceptibility, however, our observation that stem cell activation leads to
clonal expansion after injury could, in the context of additional mutations, promote the development of cancerous or precancerous lesions from activated stem cells," Giangreco added.
