Standard diagnostic tools include measurements of pocket depths, measurement of clinical attachment levels
, radiographic examination to ascertain bone loss, visible signs of gingival inflammation such as bleeding on probing, presence of suppuration and tooth mobility.
Measurements of clinical attachment levels
of Group T1 and Group T2 were also compared with control group which yielded statistically significant results as expressed in Table 3.
In cases, the probing depth, clinical attachment level
were negatively correlated with the thickness of attached gingiva with a Karl Pearson's correlation coefficients of 0.
Following completion of the questionnaire, the enrolled subjects received a full clinical examination that included plaque index (PI)18, bleeding upon probing (BOP)19, probing pocket depth (PPD) and clinical attachment level
Table 1 - The mean [+ or -] SD Values for the Age, Probing Depth (PD), Clinical Attachment Level
(CAL) and the Initial and Final force in Study Population.
Clinical parameters such as presence (score 1) or absence (score 0) of plaque accumulation, gingival bleeding, bleeding on probing, suppuration and measures of pocket depth (PD, mm) and clinical attachment level
(CAL, mm) were determined at the baseline visit at 6 sites per tooth (mesiobuccal, buccal, distobuccal, distolingual, lingual and mesiolingual) in all teeth excluding the third molars.
Clinical response was measured using pocket depth, gingival recession, clinical attachment level
, plaque index, and gingival index.
Clinical attachment level
(CAL) was calculated as the sum of the PD and GR values for each site.
In this study, a single examiner, who was blind as to treatment group, evaluated Plaque, Probing Pocket Depth (PPD), Bleeding on Probing (BOP), Clinical Attachment Level
(CAL), Dentin Sensitivity, and Perception of Discomfort at baseline, 1 month, and 4 months after treatment.
Efficacy data to be presented include significant findings at 9 months in clinical attachment level
(CAL) gain and probing pocket depth (PD) reduction in the Periostat group, both parameters showing mean improvement in excess of 2mm in sites with severe disease at baseline.
Clinical studies have shown that Periostat administered after SRP improved clinical attachment level
by up to 52% and reduced pocket depth by as much as 67% compared to SRP plus placebo.
Mechanical therapy, including periodontal debridement or scaling and root planing, has been shown to effectively reduce periodontal pathogens, inflammation, bleeding and probing depths, and to increase clinical attachment levels