(15.) Whittle BA, The use of changes in capillary permeability
in mice to distinguish between narcotic and non-narcotic analgesics, Brit J Pharmacol 22, 246-253, 1964.
The acute vascular process results from vasodilation and capillary permeability
accentuation and leads to hyperemia and edema formations at the inflammatory site.
HCSE has been reported to reduce abnormally increased capillary permeability
(Diehm 1996) and to improve venous emptying (Pittler 1998).
* Increased capillary permeability
or vascular disruption (e.g.
GE also introduced CT analysis software, Perfusion 4 Neuro, for use in the assessment of perfusion, blood volume, and capillary permeability
changes that may relate to stroke or tumor angiogenesis.
Most breast cancers enhance rapidly after IV injection of contrast agents because of higher vascularity and the angiogenic factors that produce an increase in capillary permeability
, changes in osmolar pressure, and expansion of the interstitial space, the investigators said.
VEGF activates VEGF receptor-2 (VEGFR-2/FIk-1/KDR) and increases capillary permeability
by tyrosine phosphorylation of the interendothelial adhesion molecule VEcadherin (Esser et al.
The porosity of the endothelial layer increases capillary permeability
, the meshlike structure of the basement membrane provides a barrier to large molecules, and the portal structure allows maintenance of an intracapillary pressure that favors filtration.
In addition, this ingredient, called escin, decreases capillary permeability
. For this reason, it's become a popular herb to use to prevent varicose veins and support the health and strength of all veins.
The permeability defect theory proposes that NPE is caused by a neurally induced increase in capillary permeability
without a precipitant increase in microvascular pressure. It is suggested that stimulation of the sympathetic nerves to the lung could directly affect vascular permeability by altering the number and dimensions of the endothelial pores, thus allowing fluid to enter the interstitial space.
Protein analysis has been proposed to improve classification into transudates or exudates based on the assumption that large proteins are present only in exudates because of the increased capillary permeability