According to the company, Busulfan
Injection is indicated for use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous leukemia.
By 2004 occupational exposure to 7 cytostatics from IARC group 1 had been reported, i.e., azathioprine, busulfan
, chlorambucil, cyclophosphamide, cyclosporin, chlornaphazine, melphalan and cisplatin.
The diplotype of the glutathionine S-transferase gene, which functions in catabolizing busulfan
and the metabolites of cyclophosphamide, is an independent protective factor against aGvHD (54).
"The FDA approval of Busulfan
continues to expand our portfolio of difficult to manufacture injectables, in addition to becoming our second oncology generic drug," said Nexus Chief Commercial Officer Omair Ahmed.
Transplantation was performed from the 45-year old fully HLA compatible sister donor with 6.5x10/kg CD34+ PSC infusion using Bu12,8Flu180ATG10 (Busulfan
, Fludarabin, Anti-Thymocyte globulin) preparation regimen.
The drugs commonly causing pigmentation are cyclophosphamide, hydroxyurea, doxorubicin, cisplatin, fluorouracil, etoposide, busulfan
reported their single institution outcomes of allo-HSCT patients with NHL receiving the combination of busulfan
and cyclophosphamide (Bu/cy) as the preparative regimen. Regimen of Bu/cy not only showed an acceptable toxicity but also achieved favorable outcomes particularly in younger patients.
BKV infeksiyonu disinda hemorajik sistit gelismesiyle iliskili diger onemli risk faktorleri arasinda uyumsuz akraba donor, yuksek yogunluklu hazirlama rejimi (ATG, siklofosfamid, IV busulfan
) ve radyoterapi yer alir (16,17).
, cyclophosphamide and fractionated total body irradiation for autologous or syngeneic marrow transplantation for acute and chronic myelogenous leukemia: Phase I dose escalation of busulfan
based on targeted plasma levels.
 Similarly, Aspen, which is the dominant firm in the provision of Leukeran (chlorambucil), Alkeran (melphalan) and Myleran (busulfan
) in SA, has seemingly taken advantage of their monopoly in the market and are under investigation for excessive pricing of these medicines.
Besides the Revela and Kenalog-40 generics, other recent launches from Amneal include busulfan
injection 60 mg/10 ml (6 mg/1 ml), a generic version of Busulfex; progesterone capsules in 100 mg and 200 mg strengths, a generic of Prometrium; bumetanide tablets in 0.5 mg, 1 mg and 2 mg strengths, a generic of Bumex; ezetimibe and simvastatin tablets, a generic of Vytorin; and clonidine HC1 extended-release tablets in 0.1 mg strength, a generic of Kapvay.
(10) Allojenik kok hucre transplantasyonu yapilan myeloid losemi tanili 48 hasta ile yapilan yari deneysel calismada, Busulfan
(3 gun busulfan
, FB3) tedavisi alan hastalarda (n=27) Mephalan (FM140) tedavisi alan hastalara (n=21) gore istatistiksel olarak anlamli bir sekilde (p=0.013) daha siddetli stomatit gorulmustur.