The work group concluded that a MenB booster dose
is necessary to sustain protection against serogroup B disease in persons at increased risk during an outbreak, and that the potential benefits outweighed the harms given the seriousness of meningococcal disease.
ACIP will consider MenB vaccine booster doses
for persons at increased risk for serogroup B meningococcal disease as data become available.
Seroepidemiologic studies assessing levels of antidiphtheria antibodies in adults who received a booster dose
of vaccine * Study population Ref.
coli inactivated vaccine, the geometric mean of MAT was increased from 67.27 at 1st week to 160 at 3rd week then decreased to80 at 2nd week post booster dose
, then increased to 160 at 3rd week after booster dose
, while the titer after challenge became 80.
PPRV primed goats when received the booster dose
of the respective vaccine showed higher antibody response than the primed goats after 30 days post boosting (Figure 3).
TABLE 1 Recommended Menactra schedule for young children at high risk for invasive meningococcal disease (8) Booster dose
, if Primary vaccination child remains at Risk group series increased risk Children ages 9-23 2 doses, 3 months Initial booster 3 months at high risk apart Catch-up dose years after for invasive at earliest completing primary meningococcal opportunity if dose series disease, * except 2 is not given on those with schedule At 5-year intervals functional or after initial anatomic asplenia booster Children with 2 doses, 2 months functional or apart, starting at anatomic asplenia at age 2 years and high risk for [greater than or invasive equal to] 4 weeks meningococcal after completing the disease PCV13 vaccine series PCV, pneumococcal conjugate vaccine.
Participants who had completed the primary series vaccination were eligible to receive a booster dose
of the same vaccine at 18-19 months of age.
However, the sizable minority of the panel who opposed the addition of the booster dose
for 16-year-olds cited cost and lack of cost-effectiveness.
A THE booster dose
is given before children start school.
It was decided in conjunction with HPA guidelines that 78 staff who had been in close contact with the patient should be offered antibiotics and a booster dose
of the vaccine against diphtheria.
"Wales is achieving high levels of pneumococcal vaccination and the launch of this report provides another opportunity to raise awareness of the disease and to emphasise the need for continued uptake of the vaccine, particularly the booster dose
, in all communities in Wales."
ONE child in six in Wales is without protection from potentially life-threatening disease after missing the booster dose
of a vaccine.