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If we can see that the blood-brain barrier is damaged, we can perhaps begin contemplating clinical strategies to treat the cause.
The images also revealed that older people with slight memory and learning difficulties had substantially more blood-brain barrier deterioration than healthy people of similar ages.
Now Whitehead Institute scientists report that as the developing larval fruit fly brain grows by cell division, it instructs subperineurial glia (SPG) cells that form the blood-brain barrier to enlarge by creating multiple copies of their genomes in a process known as polyploidization.
The blood-brain barrier is important to the defense of vulnerable brain tissue, but it can also restrict the ability of medications to enter the brain to fight infection and disease.
Also, the National Institute of Neurological Disorders and Stroke (NINDS) Neuroscience at the New Millennium Plan clearly identifies research on the blood-brain barrier as a scientific priority.
Furthermore, the hyaline barrier provides protection of the embryo from charged molecules, just as the placenta and blood-brain barrier do for the fetal mammalian brain, and the technique of transient dehyalination can therefore be used to model the protective effect of these diffusion barriers against potential toxicants.
Today's announced milestones support Impel technology's ability to enable CNS molecules that were previously unable to cross the blood-brain barrier to become useful therapeutics and improve product profiles of CNS drugs by improving efficacy and reducing side effects in a practical and convenient dosage form.
Professor Broden pointed out that the biggest challenge in medical treatment of diseases of the brain is that the drug cannot pass through the blood-brain barrier.
Accessory mechanisms of sensitivity may involve both increased blood-brain barrier permeability, induced by peroxynitrite, and cytochrome P450 inhibition by nitric oxide.
MMPIs appear to inhibit the action of enzymes that are needed to ferry T and B cells through the protective blood-brain barrier and into the central nervous system.
The major challenge to CNS drug delivery is the blood-brain barrier (BBB), which limits the access of drugs to the brain substance.
The blood-brain barrier effectively separates circulating blood from the fluid that bathes the brain, and it keeps out bacteria, viruses and other agents that could damage it.