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Although only 3 infants had detectable antibody titers at 6 months of age, our study estimates the biological half-life of EV71 maternal antibodies to be 42 days, similar to the half-lives of antibodies to other pathogens calculated by using longitudinal analysis (1; M.
However, in certain indications, some of their features can be detrimental: stimulation of the immune system via the antibody effector region; bivalent binding or crosslinking of the antigen; or the antibodies long biological half-life.
PolyXen is designed to improve the stability, biological half-life and immunologic characteristics of therapeutic proteins naturally.
Delayed drug absorption due to altered gastric emptying can result in therapeutic failure, especially if the drug has a short biological half-life.