Together the similar significant reduction of both of these angiogenic vasoregulatory factors significantly correlated with the beta-amyloid peptide
plaque burden strengthens and further points to vascular, and specifically microvascular, dysfunction as being significant and potentially a contributory pathophysiologic factor in AD development.
Protection against beta-amyloid peptide
toxicity in vivo with long-term administration of ferulic acid.
Beta-secretase cleaves APP at one end of the beta-amyloid peptide
; sAPP[beta] is released into the space outside the neuron.
"It identifies another pathway that's important in regulating levels of beta-amyloid peptide
," reports Dwain Thiele, chief of hepatology.
The failure of several recent treatment trials directed at the beta-amyloid peptide
, a key pathological correlate of Alzheimer's disease, suggests a need to explore alternative approaches to Alzheimer's disease treatment that are not focused on beta-amyloid metabolism," they said.
Using mouse models, researchers found that restricting caloric intake overall, and carbohydrate intake in particular, triggered brain activity associated with longevity, reducing the build-up of beta-amyloid peptide
, the main component of the plaque build-up in the brains of AD patients.
The Alzheimer's patients had significantly less beta-amyloid peptide
and more tau protein in their spinal fluid than people in the other three groups did, says study coauthor Christoph Hock of the University of Zurich.
In research so far, a synthetic form of the beta-amyloid peptide
, called AN-1792, was injected into six-week-old mice.
Alpha2-macroglobulin associates with beta-amyloid peptide
and prevents fibril formation.
In addition, unpublished work by this team suggests that apo E-IV leads to denser deposits of the beta-amyloid peptide
implicated in Alzheimer's disease.
Like the beta-amyloid peptide
, this 37-amino-acid particle, called amylin, aggregates; but instead of forming plaques in the brain, as beta-amyloid does, amylin accumulates near insulin-producing beta cells located in the pancreas.
Central to the development of Alzheimer's disease is beta-amyloid peptide
, a substance normally produced in the brain but which in Alzheimer's is deposited abnormally.