Administration of inhaled beta agonists
may reverse hypoxic pulmonary vasoconstriction by beta 2 stimulation, increasing perfusion to underventilated lung regions.
The current impasse over beta agonists
and ractopamine in particular poses a number of especially difficult challenges for the U.S.
Conducted by the NHLBI's Asthma Clinical Research Network, the study compared three treatment methods: doubling the dose of inhaled corticosteroids alone, supplementing a low dose of inhaled corticosteroids with a long-acting beta agonist
(salmeterol), and supplementing a low dose of inhaled corticosteroids with a long-acting anticholinergic drug (tiotropium bromide).
That recommendation--to use a long-acting beta agonist
(LABA) for "the shortest period of time required to achieve control of asthma symptoms and [to discontinue it], if possible, once asthma control is achieved," then use an asthma controller medication to maintain control--has raised concerns among some asthma treatment experts, who said this could be confusing for clinicians and patients.
The patients who were randomized had to meet the inclusion criteria established for the study: (a) a forced expiratory flow in 1 second (FE[V.sub.1]) between 50-85% of the predicted value after withholding their beta agonist
for at least 6 hours, (b) 15% FE[V.sub.1] improvement 20-30 minutes after beta-agonist use in at least two pre-study evaluation visits, and (c) demonstrated competence using a peak flow meter and a diary card used to track asthma symptoms.
OBJECTIVE: This study evaluated whether chiropractic treatment was an alternative to long acting beta agonists
in terms of improving quality of life and reducing rescue bronchodilator use.
For many of us, long acting beta agonists
are still new, compared to short acting agents.
Another class of drugs, beta agonists
, such as albuterol, bitolterol, metaproterenol, pirbuterol, and terbutaline, are used either when the symptoms occur or just before an activity that may cause symptoms.
Because of the phaseout of CFC propellant in beta agonists
and the increased deposition seen with other HFA MDIs.
These agents work well with beta agonists
as well as on their own.
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommends long acting beta agonists
be added to the treatment of patients in stage II.