Unfortunately, it is predicted that none of the cranioplasty materials are as capable as autologous grafts. Various studies showed that these materials may result in graft rejection, parenchymal defects, and infection in the early or late period (8-12).
Various autologous grafts have been described in the literature, including the great saphenous vein, internal jugular vein, femoral vein, left renal vein, or gonadal veins [11,12, 31-33].
Reviroc is under development for the elimination of cancer cells from an autologous graft in bone marrow transplantation for end-stage blood cancer patients.
Some cancers may reside in an autologous graft. Therefore, transplants using autologous material from bone marrow, mobilized stem cells from peripheral blood, or UCB are less likely to be indicated for hematologic malignancies.
Among other activities, the companies will co-fund Genzyme's ongoing Myoblast Autologous Graft in Ischemic Cardiomyopathy (MAGIC) Phase 2 clinical trial of cell therapy to repair damaged heart tissue.
"The regenerative mechanisms of the body are extremely complex, "Pavesio said." To date, the standard of care in just about any [orthopedic] surgery remains an autologous graft because it is very, very hard to synthetically reproduce a tissue, considering all the complexity that goes into it.