Conditioning including
antithymocyte globulin followed by unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation can achieve comparable outcomes with HLA-identical sibling transplantation.
LeMauff et al., "Mechanisms involved in
antithymocyte globulin immunosuppressive activity in a nonhuman primate model," Transplantation, vol.
The cumulative dose of rabbit
antithymocyte globulin (ATG) reached 6mg/kg (total of 575 mg).
The strengths of this study include looking at the kinetics of chimerism and not at just one point of time chimerism and a cohort of adult patients with only myeloid malignancies treated at a single center by the same physicians with uniform peripheral blood stem cell grafts and the widely used Bu based myeloablative preparative regimens with the standard-of-care methotrexate/tacrolimus-based with or without
antithymocyte globulin GVHD prophylaxis.
Maki and his colleagues recently found that an animal form of
antithymocyte globulin reversed diabetes in mice more effectively when they added the drug exendin-4 to the treatment.
After French physicians began adding
antithymocyte globulin (ATG) to the standard busulfan and cyclophosphamide regimen in 1992, none of the 57 children who received the treatment rejected their stem cell transplant.
Randomized controlled trial of a monoclonal antibody against the interleukin-2 receptor (33b3.1) as compared with rabbit
antithymocyte globulin for prophylaxis against rejection of renal allografts.
These include mycophenolate mofetil (MMF) or enteric-coated mycophenolate sodium (EC-MPS) [3-5], ganciclovir/valganciclovir [3, 6, 7],
antithymocyte globulin (ATG) [8, 9], tacrolimus [10, 11], sirolimus [12], and cotrimoxazole [13, 14].
Induction immunotherapy prior to re-transplantation consisted of
antithymocyte globulin (ATG) and methylprednisolone.
The treatment options of HS are corticosteroids, immunoglobulins, etoposide,
antithymocyte globulin, cyclosporine, and stem cell transplantation [9].
The bone marrow did not reconstitute, and 35 days after the initial transplant, the patient received a second SCT from the same donor after a conditioning regimen with
antithymocyte globulin. Engraftment took place on day 49, 14 days after the second transplant.
