It can be used alone or in combination with methyl prednisolone or along with
antithymocyte globulin.
Systemic lupus erythematosis with severe aplastic anemia successfully treated with rituximab and
antithymocyte globulin.
Attempts to combine this with other immunosuppressive regimens, particularly
antithymocyte globulin, were unsuccessful and further evaluation of this approach is awaited.
Antithymocyte globulin has limited efficacy and substantial toxicity in unselected anemic patients with myelodysplastic syndrome.
Maki and his colleagues recently found that an animal form of
antithymocyte globulin reversed diabetes in mice more effectively when they added the drug exendin-4 to the treatment.
After French physicians began adding
antithymocyte globulin (ATG) to the standard busulfan and cyclophosphamide regimen in 1992, none of the 57 children who received the treatment rejected their stem cell transplant.
1) as compared with rabbit
antithymocyte globulin for prophylaxis against rejection of renal allografts.
She received alemtuzumab with her first allogeneic transplant and conditioning with
antithymocyte globulin before her second transplant, resulting in significant in vivo T-cell depletion; she was also receiving adrenal corticosteroids.
Successful treatment of acquired amegakaryocytic thrombocytopenic purpura refractory to corticosteroids and intravenous immunoglobulin with
antithymocyte globulin and cyclosporin.
Patients were then immunoablated with a combination regimen of high-dose cyclophosphamide, a total of 200 mg/kg, along with equine
antithymocyte globulin to eliminate T cells.
He received induction immunosuppression with
antithymocyte globulin and maintenance immunosuppression with cyclosporine A (CsA), azathioprine, and prednisone.
Starzl Transplantation Institute treated 82 patients with rabbit
antithymocyte globulin for T-cell depletion just before transplantation and with only 1 immunosuppressant after transplantation, rather than the usual 2- or 3-drug cocktail.
