As a case in point, I am not satisfied that we have sufficiently examined immunity to the N1 antigen
of the H5N1 pandemic-candidate virus.
capsulatum infection (CF antibodies to the mycelial and/or yeast-phase antigen
at a titer of [greater than or equal to] 1:32, H and/or M band by immunodiffusion, seroconversion of negative to positive H and/or M immunodiffusion band, a [greater than or equal to] 4-fold rise in CF titer between acute and convalescent sera, or urinary H.
These cells then apparently use the antigens
and other molecules within the exosomes to stimulate the activity of T cells, the true warriors of the immune system.
So, the theory goes, when a person with slightly abnormal MHC proteins (perhaps enabling what ought not to be enabled) is exposed to a virus or bacterium with myelin look-alike antigens
on board, a few T cells are primed to attack myelin wherever it is encountered again.
Because the enzyme enhances the reaction to extremely small amounts of antigen
, attention must be given to the avoidance or elimination of potential antigens
in the environment to which the patient is exposed a few days before and a few days after each injection.
Lehmann, examined the reaction of newborn mice to antigens
mixed with two different types of oils, called adjuvants, which are used in laboratory experiments to excite the immune system.
Review of industry and academic stakeholder opinions involved in the vaccine antigen
Family 2 is directed to cancer antigens
believed to be capable of stimulating anti-cancer immune responses.
Mast cells challenged with antigen
express and secrete to supernatant several proinflammatory cytokines including IL-4.
The vaccine antigens
have been fused to ubiquitin, which has been shown to enhance MHC presentation and CTL responses.
Once the different antigens
have been evaluated for reactivity in this manner, a treatment vial can be mixed that will include each clinically pertinent antigen
at its individual endpoint concentration.
In initial trials, people with lymphoma, melanoma, or prostate cancer who received dendritic cells primed with a known tumor antigen
showed strong anticancer immune responses (SN: 1/13/96, p.