# Alpha

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Related to alpha-fetoprotein: carcinoembryonic antigen, Alpha-Fetoprotein Test

## Alpha

Measure of risk-adjusted performance. Some refer to the alpha as the difference between the investment return and the benchmark return. However, this does not properly adjust for risk. More appropriately, an alpha is generated by regressing the security or mutual fund's excess return on the benchmark (for example S&P 500) excess return. The beta adjusts for the risk (the slope coefficient). The alpha is the intercept. Example: Suppose the mutual fund has a return of 25%, and the short-term interest rate is 5% (excess return is 20%). During the same time the market excess return is 9%. Suppose the beta of the mutual fund is 2.0 (twice as risky as the S&P 500). The expected excess return given the risk is 2 x 9%=18%. The actual excess return is 20%. Hence, the alpha is 2% or 200 basis points. Alpha is also known as the Jensen Index. The alpha depends on the benchmark used. For example, it may be the intercept in a multifactor model that includes risk factors in addition to the S&P 500. Related: Risk-adjusted return.

## Alpha

1. The measure of the performance of a portfolio after adjusting for risk. Alpha is calculated by comparing the volatility of the portfolio and comparing it to some benchmark. The alpha is the excess return of the portfolio over the benchmark. It is important to Markowitz portfolio theory and is used as a technical indicator.

2. The excess return that a portfolio makes over and above what the capital asset pricing model estimates.

## alpha

The mathematical estimate of the return on a security when the market return as a whole is zero. Alpha is derived from a in the formula Ri = a + bRm which measures the return on a security (Ri) for a given return on the market (Rm) where b is beta. See also capital-asset pricing model, characteristic line.

## Alpha.

Alpha measures risk-adjusted return, or the actual return an equity security provides in relation to the return you would expect based on its beta. Beta measures the security's volatility in relation to its benchmark index.

If a security's actual return is higher than its beta, the security has a positive alpha, and if the return is lower it has a negative alpha.

For example, if a stock's beta is 1.5, and its benchmark gained 2%, it would be expected to gain 3% (2% x 1.5 = 0.03, or 3%). If the stock gained 4%, it would have a positive alpha.

Alpha also refers to an analyst's estimate of a stock's potential to gain value based on the rate at which the company's earnings are growing and other fundamental indicators.

For example, if a stock is assigned an alpha of 1.15, the analyst expects a 15% price increase in a year when stock prices are generally flat. One investment strategy is to look for securities with positive alphas, which indicates they may be undervalued.

References in periodicals archive ?
Estimating a women's risk of having a pregnancy associated with Down syndrome using her age and serum alpha-fetoprotein level.
Kohlwes, "Test characteristics of alpha-fetoprotein for detecting hepatocellular carcinoma in patients with hepatitis C.
Increased GABAergic activity inhibits alpha-fetoprotein mRNA expression and the proliferative activity of the HepG2 human hepatocellular carcinoma cell line.
Cheng, "Early alpha-fetoprotein response predicts treatment efficacy of antiangiogenic systemic therapy in patients with advanced hepatocellular carcinoma," Cancer, vol.
Placenta accreta is associated with elevated maternal serum alpha-fetoprotein. Obstet Gynecol.
Alpha-fetoprotein: In growth of embryo have two major blood proteins as albumin and alpha-fetoprotein (AFP).
NEW ORLEANS -- A combination of ultrasound and alpha-fetoprotein testing identified almost all hepatocellular carcinomas in patients with cirrhosis associated primarily with chronic hepatitis C, according to the findings of a retrospective study.
Additional RISH probes under development include alpha-fetoprotein, calcitonin, cytomegalovirus, gastrin, insulin, pancreatic peptide, and more.
has obtained exclusive worldwide rights to the development and commercialization of recombinant human alpha-fetoprotein for the treatment of autoimmune diseases from Merrimack Pharmaceuticals.
For testicular cancer, alpha-fetoprotein, human chorionic gonadotropin, and lactate dehydrogenase are recommended for diagnosis/case finding, staging, prognosis determination, recurrence detection, and therapy monitoring.
The development of hepatocellular carcinoma can be excluded by lack of rise of alpha-fetoprotein and absence of hepatic focal lesions (9).
Immunohistochemical staining for alpha-fetoprotein (AFP) and cytokeratin were performed in selected slides.

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