(13) Kendall isolated 6 active adrenocortical hormones
from the adrenal gland and named them in the order in which they were isolated, i.e., Compound A through F (Compound A is 11-dehydrocorticosterone, Compound B is corticosterone or Reichstein's substance H, Compound C is 5[alpha]-pregnane-3[alpha], 11[beta], 17[alpha], 21-tetrol-20-one or Reichstein's substance C, Compound D is 5[alpha]-pregnane-3[beta], 11[beta], 17[alpha], 20[beta], 21-pentol or Reichstein's substance A, Compound E is cortisone or Reichstein's substance F, and Compound F is cortisol or Reichstein's substance M).
Based on these results and in previous studies [22, 24-26], we can assume that there are two distinct groups of PCOS: one composed of nonobese, noninsulin resistant women, showing higher levels of LH and adrenocortical hormones
(cortisol and DHEA-S) and another composed of obese, insulin resistant women showing lower levels of LH and adrenocortical products.
Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones
. In: Hardman JG, Limbird LE, Gilman AG, editors.