Among the strategies researchers used to inhibit adenosine
activity was the experimental compound FR194921, which selectively blocks the A1 receptor.
was administered to rats by gavages at a dose of 150 mg/kg body weight, according to Mabley et al.
deaminase levels showed significant elevation (p value <0.
The diagnostic value of adenosine
deaminase activity in sputum in pulmonary tuberculosis.
In 520 patients' adenosine
exercise (adenoEx) resting first protocol was implemented (fig-1) and in remaining 308 patients who could not perform physical stress; adenosine
(Adeno) resting first protocol was utilized (fig-2).
These studies have mainly followed two algorithms to assess the utility of adenosine
According to the adenosine
test, 122 patients were sensitive, and 94 patients were insensitive.
Methotrexate enhances the generation of multinucleated giant cells in vitro, as does adenosine
A1 receptor occupancy, while an A1 receptor antagonist reverses these effects.
lasts only minutes in the human body, so injections of the chemical itself were not an option.
Professor Fredholm's research on adenosine
and its receptors has significantly contributed to the current understanding of CNS mechanisms in health and disease.
who presented the findings of a study that confirmed adenosine
as a key factor in the anticonvulsant effect of the ketogenic diet.
Masino and her colleagues found that mice with normal levels of adenosine
A1 receptor (ALP,) and a transgenic overexpression of adenosine
kinase, an intracellular enzyme that negatively influences extracellular levels of adenosine
, had a "near complete" reduction in the number and duration of spontaneous seizures.