Role of proton pump inhibitor on esophageal carcinogenesis and pancreatic
acinar cell metaplasia development: an experimental in vivo study.
Histopathologically, ACCs are defined by serous and
acinar cell differentiation.
Tissue edema, leukocyte infiltration,
acinar cell necrosis, and hemorrhage were the pathological changes observed in this model.
Oxygen free radicals generated during acute pancreatitis not only cause pancreatitis
acinar cell damage but also contribute to the pancreatic damage [26, 27].
Simultaneously, TR[beta] also promoted the proliferation of pancreatic exocrine
acinar cells. However, the role that TR[alpha] seemed to play is more important, since they have a role in transforming elastase-expressing pancreatic
acinar cells into synthesized insulin-producing cells.
Transmission electron micrograph of 49.5 cm CVRL (185th day) buffalo foetus showing myoepithelial cell (MEC) at the base of the
acinar cell of parotid gland.
(2013) The role of protein synthesis and digestive enzymes in
acinar cell injury.
More recently, studies have turned to determining effects of alcohol on the pancreatic duct cell, which is important for producing fluid secretion and carrying digestive enzymes secreted by the
acinar cell into the gut lumen, where they are needed for meal digestion.
Biankin et al., "Notch inhibits Ptf1 function and
acinar cell differentiation in developing mouse and zebrafish pancreas," Development (Cambridge, England), vol.
The histopathology scoring criteria were edema,
acinar cell necrosis, hemorrhages, and inflammation.
Fibrosis,
acinar cell degeneration, and tubular complexes [4] were seen in the surrounding tumor-free pancreatic tissue.
Pancreatic
acinar cell carcinoma (PACC) is a rare tumor that accounts for approximately 1% of malignant pancreatic neoplasms [1].