For people who've had a heart attack in the past, the absolute risk
of having a heart attack during any given hours is 10 in 1 million.
The relative risk of major adverse cardiovascular events was highest in individuals with low or moderate baseline risk, while the highest absolute risk
was seen for individuals with high baseline risk.
Only 1.6% of the men receiving zole-dronic acid developed new vertebral fractures, compared with 4.9% of those receiving placebo, a difference that corresponded with an absolute risk
reduction of 3.3 percentage points and a relative risk reduction of 67%.
But the agency noted that the absolute risk
of adverse cardiovascular events with Chantix, in relation to its efficacy, is small,
So the absolute risk
of cardiovascular problems among people taking painkillers was low, but the researchers did find that, relative to placebo, the drugs carried important risks.
"Although a number of studies have demonstrated an association between complex migraine and stroke, it is important to keep in mind that the overall absolute risk
of stroke in otherwise healthy migraineurs remains very low.
In the Multiple Outcomes of Raloxifene Evaluation, or MORE trial, which evaluated women who had osteoporosis rather than a high risk of invasive breast cancer, the absolute risk
reduction for invasive breast cancer was 3.1 fewer cases for every 1,000 woman-years of raloxifene use) The number needed to treat (NNT) to prevent one case of cancer: 323 women for i year.
Therefore, compared with non-drinking women, women consuming 2 or more drinks per day had an absolute risk
increase of 0.66 events/1 000 person-years.
The study said: "The absolute risk
of unexplained stillbirth at or after 39 weeks' gestation was 1.1 per 1000 women who had had a previous Caesarean section and 0.5 per 1,000 in those who had not.
And even for patients wearing soft lenses overnight, the absolute risk
of keratitis remains less than 1 percent, says Peter C.
The researchers said that although the increased stroke risk associated with depression was large, the absolute risk
of stroke is still fairly low for women of that age.
"While the relative risk of developing breast cancer in increased, the absolute risk
associated with [HT] are low," she said.