Because the
side chain of salmeterol is anchored at the exosite, the active head portion continually attaches to and detaches from the receptor site.
The cycloaliphatic epoxy resin was mixed with different amounts of the copolymer having a fluorinated
side chain. An accelerator was added at 3 phr for the total amounts of the epoxy resin and copolymer.
In other words, the largest tensile strength of the blends increased as the
side chain content of compatibilizers increased.
We speculated that the unique three-dimensional shape of the lipophilic
side chain may play an important role in allosteric activation of the channels through hydrophobic interactions.
There is evidence that the beneficial effect of MK-4 on bone health may be due more to its
side chain than to its vitamin K activity, which might explain why pharmacological doses appear to be necessary to achieve the observed effect.
Reduced testosterone levels were accompanied by the decreased expression of StAR (steroidogenic acute regulatory protein) and 3[beta]-HSD (3[beta]-hydroxysteroid dehydrogenase), as well as increased levels of P450scc (cytochrome P450
side chain cleavage), in Leydig cells.
However, a glutamate (E) paired with an aspartate (D) will still give a player 2 points (the only difference between these two amino acids is a methenyl group (CH2) in the
side chain).
Tocotrienols isoprenoid
side chain has three double bonds as compared to tocopherol's saturated
side chain.
Recent developments include (1) an optimization method for
side chain identification and fitting based on the Nelder-Meade Simplex algorithm; (2) identification of noncrystallographic symmetry through pattern recognition in real-space (that is, electron density), which can be used to improve phases; and (3) the use of selenium sites from seleno-methionine MAD experiments to enhance
side chain building and sequence alignment through identification of methionine residues.
A comprehensive review of the evidence shows that the attributable risk of a cross-reactive allergic reaction varies and is strongest when the chemical
side chain of the specific cephalosporin is similar to that of penicillin or amoxicillin.