The primary objectives of the study are to evaluate safety, tolerability, and the effect of vosoritide on height Z-scores
, which is the number of standard deviations in relation to the mean height of age-matched, average stature children.
For instance, a longitudinal study found an inverse association between diet quality and changes in BMI z-scores
in children 5-12 years old who were overweight at the initial visit, but not in those with normal weight (27).
Lower lumbarand femoral Z-scores
in ACPA-positive patients were reported (14).
 that evaluated the adult survivors of childhood ALL, it was stated that very low BMD was relatively unusual and that the BMD Z-scores
tend to improve from adolescence to young adulthood.
For example, in 2017, stocks with high Z-scores
had median price to earnings (P/E) ratio of 20 times while those with Z-scores
of 1.81 and below had only a median P/E of 10 times.
The median body mass index z-scores
of the study cohort (adolescent growth spurts typically influence the body mass index z-scores
for both sexes, for girls at the age of 11-12 years old and 14-15 years, and for boys at the age of 13-14 years old and 16-18 years old)
Table 1 Location z Results Baseline Test Difference z P z P z P P1 +0.40 ns -2.58 .045 -2.98 .082 P2 -1.63 ns +1.35 ns +2.98 .082 P3 +0.25 ns +0.82 ns +0.57 ns P4 +2.49 .041 +1.08 ns -1.41 ns P5 -2-19 .069 +2.30 .055 +4.49 .011 Training M(SD) [r.sup.s] (a) P1 +0.13 (1.23) -.02 P2 -0.10 (1.15) -.34 P3 +0.23 (1.14) +.20 P4 +0.06 (0.68) -.34 P5 -0.15 (1.51) +.12 (a) Spearman correlations between trial numbers and location z-scores
. All are nonsignificant.
An analysis of the mean z-scores
for BMI-for-age confirms the above results (Table 5).
FI, LDL-C, TG and AI, as well as BMD, BMD z-scores
for CA and BA were statistically similar at baseline and at the six-month follow-up (Table 2B).
Table 2 lists the Z-scores
for weight, length, and head circumference of each group.
Sequencing data were used to calculate Z-scores
, which are estimates of normalized chromosomal representation compared with a euploid genome.
The mean z-scores
of both weight and height for age were shown to decrease as the number of sensitized food allergens increased .