Three SNPs of XPF, XPF rs180067, rs1799801 and rs2276466, were genotyped by Taqman real-time PCR method with a 7900 HT sequence detector system.
We did not find the significant difference in the genotype distributions of XPF rs180067, rs1799801 and rs2276466 between cases and controls.
Genotyping of XPF: We selected potential functional SNPs of interested XPF from Database of single nucleotide polymorphisms (SNPs) of NCBI (http://www.
The genotype distributions of XPF rs180067, rs1799801 and rs2276466 in cases and controls is summarized in Table-II.
Table-II: Frequency distribution of XPF SNPs polymorphisms and their association with gastric cancer risk
A further association analysis was conducted to evaluate the association of XPF rs180067, rs1799801 and rs2276466 with risk of gastric cancer by stratifying H.
To the best of our knowledge, this study is the first attempt to evaluate the potential association between the three selected SNPs of XPF and risk of gastric cancer in Asian population.
However, a few studies have investigated the association between XPF SNPs and risk of gastric cancers, and only two studies reported their association.
1] TLR4 (endotoxin) Hay dust TNF-[alpha] production in TNF[alpha] hypersensitivity pneumonitis Ozone Influx of inflammatory TLR4 cells in the lung Airborne PAHs PAH metabolites in urine, CYP1A1 DNA adducts, or GSTM1 measures of NAT2 genotoxicity GSTP1 EPHX1 Lung cancer GSTM1 Nitro-PAHs Genotoxic effects in NAT2 respiratory tract Ultraviolet light Basal cell carcinoma XPD Ionizing radiation DNA damage in lymphocytes XPD XPF
XRCC1 Prolonged cell cycle APE1 delay Tobacco smoke Lung cancer CYP1A1 GSTM1 NAT1 NAT2 EPHX1 XRCC1 Bladder cancer CYP1A2 NAT2 GSTM1 Bronchogenic carcinoma AHR Emphysema and chronic EPHX1 obstructive pulmonary GSTM1 disease Environmental Lung cancer GSTM1 tobacco smoke Exposure Rating (a) Reference Arsenic 3 Chiou et al.
Building work will comprise two four-inch flowlines from the well heads to a northern gathering manifold and a six-inch pipeline to carry the gas to XPF.
The initial capacity of XPF will be around 10 TJ per day, with further expansion possible, and first gas is slated for August 2016.