2012) The ubiquitin ligase XIAP
recruits LUBAC for NOD2 signaling in inflammation and innate immunity.
Activation of NF-kappa B by XIAP
, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1.
By contrast, caspase-3 and -7 are inhibited by XIAP
and to a lesser extent, by c-IAP1, c-IAP2 and NAIP.
The researchers then found that XIAP
holding the NO 'hot potato' was much more common in brains of human patients with neurodegenerative diseases than in normal brains, solidifying their suspicion that this protein modification leads to cell damage.
Unlike previously known XIAP
inhibitors, these compounds directly kill a broad range of solid-tumor cells and leukemia cells, Reed and his colleagues report.
Los pacientes con cancer avanzado de prostata presentan una alta expresion de IAP, como lo han demostrado los estudios inmunohistoquimicos, con los cuales se han observado alteraciones en la expresion de cIAP1, cIAP, XIAP
y survivina en el tejido maligno, al compararlo con el epitelio normal la prostata (47, 48).
Immunohistochemical detection of p63 and XIAP
in thymic hyperplasia and thymomas.
The X-linked inhibition of apoptosis protein (XIAP
) is up-regulated in metastatic melanoma, and XIAP
cleavage by Phenoxodiol is associated with Carboplatin sensitization.
Activation of NF-[kappa]B leads to the expression of not only various proinflammatory and profibrogenic factors but also antiapoptotic proteins such as XIAP
and cellular FLIP (c-FLIPL) that might enhance the survival and proliferation of activated HSCs.