(2012) The ubiquitin ligase XIAP
recruits LUBAC for NOD2 signaling in inflammation and innate immunity.
The expression of XIAP
in bone defects of the tibia in diabetic rats was not different in the groups undergoing LLLT with the diode laser.
Recently, another report in line with the above result found that Siva-1 could balance NF-[kappa]B and JNK signaling to promote apoptosis by physically interacting with XIAP
and TAK/TAB1 to form a complex.
Differentiation between benign and malignant mesothelial proliferations still relies on the histologic features of invasion, although a few markers, such as EMA, XIAP
, and GLUT-1, seem to favor a malignant process, whereas desmin favors a benign process.
is also frequently expressed in malignant mesothelioma and is notably upregulated in mesothelioma effusions and peritoneal mesothelioma.
Mattson, "Elongation factor 2 diphthamide is critical for translation of two IRES-dependent protein targets, XIAP
and FGF2, under oxidative stress conditions," Free Radical Biology and Medicine, vol.
Similar to Smac/DIABLO, HtrA2/Omi binds to and neutralizes IAPs (XIAP
, cIAP1, and cIAP2) via its N-terminal IAP-binding motif, therefore releasing the inhibition of IAP to caspase-3, -7, and -9.
Pretreatment with cryptolepine reduced the levels of Bcl-2, cyclin D1, survivin, XIAP
, and cIAP in cells stimulated with TNF-[alpha].
Glinskii et al., "Increased expression of apoptosis inhibitor protein XIAP
contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells," Cancer Research, vol.
 found that adiponectin could improve the resistance of EPCs to apoptosis, and this effect may be mediated by XIAP
(X-linked inhibitor of apoptosis protein).
IRES elements have been identified in mRNAs encoding stress response proteins (proand antiapoptotic), such as X-linked inhibitor of apoptosis (XIAP
), cellular inhibitor of apoptosis 1 (cIAP1), B cell lymphoma extra large (Bcl-xL), Bcl-2, Bag-1, apoptotic protease activating factor 1 (Apaf-1), p53, L-myc, N-myc, c-myc, and death-associated protein 5 (DAP5) [1, 8, 32-34].
It also resulted in inhibition of pERKl-2 signaling which led to inhibition of the antiapoptotic proteins Bel-XL and XIAP
and phosphorylation activation of the proapoptotic protein Bid.