Note that the clearance, the volume of distribution
, the elimination constant, and the half-life were consistent when calculated after the first and 13th doses, despite a large decrease in dose that was initiated after measurement of the first-dose area under the time-vs-concentration curve (AUC).
Low concentrations are characteristic of chronic leiver disease, being due to both decreaswed synthesis and an increase in the volume of distribution
as a result of fluid retention and the formation of ascites.
Volume of distribution
([V.sub.d]) was calculated using the following formula:
Various methods can be found in the research literature to estimate the Widmark factor or the volume of distribution
from variables such as height, weight and age .
The apparent volume of distribution
was found to be 142.87 [+ or -] 22.78 l.
The non-linear regression program NON-MEM was used to generate population estimates of methylprednisolone volume of distribution
and clearance (removal of drug).
Steady-state volume of distribution
and total body clearance after intravenous administration were estimated to be 1.12 L/kg and 0.41 L/h per kilogram, respectively.
To understand the basic principles of pharmacokinetics such as volume of distribution
([V.sub.d]), clearance (CL), and plasma half-life ([t.sub.1/2]).
Additionally, amitriptyline produces pharmacologically active metabolites and is highly lipophilic with a large volume of distribution
. This makes management of severe overdose particularly challenging.
PP effectively clears drugs that are highly protein bound and have a small volume of distribution
. As a result, serum levels of psychotropics are lowered.
Apart from half life there is variation in other pharmacokinetic parameters like volume of distribution
(Vd), it is 217 litres in a Thai study4 and 159.2 litres in Malaysian volunteers5.
Entries are listed alphabetically and consist of the compound name and chemical structure along with information regarding half-life, volume of distribution
, fraction bound to protein, and dissociation constants.