Persistent nonmetastatic gestational trophoblastic disease
Gestational trophoblastic disease
among Hispanic women: a 21-year hospital-based study.
However, arteriovenous shunting, in itself, is a nonspecific finding that can occur in other conditions such as pregnancies, missed abortions, trophoblastic disease
, and ectopic pregnancies.
Differential expression of p57Kip2, a maternally imprinted cdk inhibitor, in normal human placenta and gestational trophoblastic disease
Hyperglycosylated hCG produced in invasive trophoblastic disease
, choriocarcinoma, and in early pregnancy displays a different structure from that of regular hCG.
Tumors of the Uterine Corpus and Gestational Trophoblastic Disease
In a recent review, the authors reported that the Siemens Immulite hCG assayis the onlyassaythat is useful for all pregnancy, gestational trophoblastic disease
, and cancer applications (1).
Patients with gestational trophoblastic disease
secrete intact hCG, hCG[beta], nicked hCG and hCG[beta], and in some cases hCG devoid of the carboxy-terminal portion of the hCG[beta] subunit and hCGh.
The second edition is enhanced with a new section introducing pelvic anatomy, a new chapter on surgical instruments, revision of the sections on pelvic floor surgery, coverage of episiotomy, major revisions to endoscopy coverage, and an entirely new unit on the female breast, intestinal surgery, and surgical treatment of trophoblastic disease
The diagnostic sensitivity of this tumor marker for detecting trophoblastic disease
is high and approaches that of an ideal tumor marker.
Aside from its synthesis during normal pregnancy, gestational trophoblastic disease
, or some malignancies, a small amount of hCG is normally produced by the pituitary gland in conjunction with the structurally similar glycoprotein hormones luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (4, 5).
Professor of Obstetrics and Gynecology Head, Obstetrics, Gynecology and Women's Health Co-Director, Upper Midwest Trophoblastic Disease
Center Co-Director, Women's Cancer Center University of Minnesota Medical School - Twin Cities Jocelyn D.