Other isolated compounds exhibited weak inhibitory effects on MMP expression (less than 20% inhibition) at minimal and moderate
toxic dose levels of 10 and 40 [micro]g/ml (dose-response data was not shown).
For chemicals that do not react with DNA, it is not appropriate to use the linearated multistage model to extrapolate cancer risks from high
toxic doses t lower nontoxic exposures.
It is embryotoxic in animals, but only at maternal
toxic doses.
In particular, IDN 5390 allows for metronomic chemotherapy treatment, which means lower, less
toxic doses over a longer treatment time.
The problems were: the oxidized form of vitamin C (dehydroascorbic acid) and not actual vitamin C (ascorbic acid) was used; and in the mouse experiments, the animals were given
toxic doses of dehydroascorbic acid, a compound that is not used as a dietary supplement in humans.
They are not teratogenic or embryofetotoxic in rats, but they have been shown to have toxic effects (abortions and stunted growth) in rabbits exposed in utero to doses at or close to maternal
toxic doses.
Scientists at the University of Wisconsin-Madison had shown that overtly
toxic doses of TCDD, the most potent dioxin, can reduce concentrations of androgens - the male sex hormones, such as testosterone - in the blood of adult animals.
James' work centers around a protein compound, called cysteine adducts, that forms with
toxic doses of acetaminophen.
For example, in one study published in the July 2004 issue of Toxicological Sciences, data from microarrays and traditional toxicity tests confirmed previous results from other labs showing that
toxic doses of acetaminophen deplete adenosine triphosphate (ATP; molecules that store cellular energy) and damage mitochondria, the organelles that produce ATP.
This is especially crucial for powerful drugs where the margin between effective and
toxic doses is narrow, said Kenneth Thummel, associate dean for research and new initiatives of the UW School of Pharmacy.
