Cucchi et al., "MEN 11420 (Nepadutant), a novel glycosylated bicyclic peptide tachykinin
NK2 receptor antagonist," British Journal of Pharmacology, vol.
The scientists posit that disruption of the tachykinin
system may contribute to AN before other phenotypes or observed characteristics become obvious, but said further studies employing larger patient cohorts are necessary.
Murillo, "Contractile effect of tachykinins
on rabbit small intestine," Acta Pharmacologica Sinica, vol.
"Effects of CP-99, 994, a tachykinin
NK1 receptor antagonist, on abdominal afferent vagal activity in ferrets: Evidence for involvement of NK1 and 5-HT3 receptors." European Journal of Pharmacology 428.2 (2001): 215-220.
Genetic association of the tachykinin
receptor I TACRI gene in bipolar disorder attention deficit hyperactivity disorder, and the alcohol dependence syndrome.
Results: The AR combination down-regulated a number of genes involved in reduction of bone resorption including cathepsin G (CTSG) and tachykinin
receptor 1 (TACR1).
Substance P (tachykinin
), glutamate, and gamma aminobutryic acid (GABA) are neurotransmitters and neuropeptides released to help propel the signal to the brain.
neurotransmitter activity changes in response to gabapentin, which may be the possible mechanism.
In this context, NGF and its high-affinity receptor tachykinin
receptor antagonist (TkrA) have been found on the human cerebellar neurons and their neurites.
The role of mast cells in tachykinin
neurogenic skin inflammation induction has been shown and thus their intense presence in PP rosacea [21, 22] may be explained.
[9.] Laird J (2001) Gut feelings about tachykinin
NK1 receptor antagonists.
Miroinjection of tachykinin
receptor agonists of NK1, NK2 and NK3 into the VTA are shown to increase BP and HR.