Cycle

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Cycle

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In ventricular myocardium, SXSM increased the supply of ATP by enhancing TCA cycle and oxidation-respiratory chain.
During MI, oxygen deficiency and oxidative stress of the heart can damage mitochondria and inhibit the activity of TCA cycle enzymes, leading to energy metabolism disorder and accumulation of related metabolites in TCA cycle (Noctor et al.
Respiratory metabolism: Glycolysis, the TCA cycle and mitochondrial electron transport.
The metabolomic data suggest disruption of the TCA cycle because decreased levels of TCA intermediates were detected in the groups exposed to [As.
of components of the pathway represented by contigs with at least a 20% increase in expression Pathway in filtered data set at noon at midnight Fatty acid degradation 12 4 0 TCA cycle 15 5 2 Glycolysis 13 3 5 Oxidative phosphorylation 43 9 4
Without going into the gory details of intermediary metabolism, it is sufficient to say that the TCA cycle produces 34 ATP molecules or 17 times that of glycolysis.
He explained that, after researchers in the 1960s concluded that cyanobacteria had an incomplete TCA cycle, that false assumption was compounded by later researchers who used modern genomics-research methods to confirm it.
TCA cycle was not operating except in the reaction converting SUC to SUCCoA, which was involved in lysine synthesis.
A complete pathway starts with the target compound and ends with metabolites that can enter the TCA cycle (Figure 2).
For example, amino acids, fatty acids and sugars are converted to acetyl CoA for entry into the TCA cycle and oxidation to energy.