In addition, the porcine P -casein gene containing the mutant TATA box (CATAAAA) was cloned from another individual pig.
Moreover, the luciferase activity of the 5'-flanking region containing the mutant TATA box in the promoter region was lower than that of the 5'-flanking region containing the normal TATA box.
0] Cd41/42-F (5) (Phe-Phe) [right arrow] TT] (or Codon 41-C, [TTC (Phe) [right arrow] TT-]) * -29 TATA box
A [right arrow] G [[beta].
The lower expression of the UGT1A gene is related to a TA insertion in the TATA box
of the gene promoter (5).
This interaction of the aromatic group of Phe with the base-pairs of DNA is reinforced by recent findings of Burley , who showed that two Phe residues of TATA box
binding protein interact with the T-A basepair by Van der Waals contacts.