Lipoxin A(4) activates alveolar epithelial sodium channel
, Na, K-ATPase, and increases alveolar fluid clearance.
Sodium bicarbonate is administered either as a continuous infusion or intermittent boluses to maintain the pH between 7.5 and 7.55 to reverse the action of sodium channel
And because NaV1.7 is also found in cells that provide users with a sense of smell, numbing this sodium channel
could trigger a loss of smell as a side effect.
BrS is an autosomal dominant, low-penetrance disease caused by several different loss-of-function gene mutations that affect the [Na.sub.v]1.5 sodium channel
Waxman, "Na v 1.9: A sodium channel
linked to human pain," Nature Reviews Neuroscience, vol.
Zheng, "Alpha2-adrenoceptor-independent inhibition of acetylcholine receptor channel and sodium channel
by dexmedetomidine in rat superior cervical ganglion neurons," Neuroscience, vol.
Antiarrhythmic agents block sodium channels
and may be used to unmask true Brugada syndrome at appropriate dosages (4).
Below we will review the utility and likely mechanisms of sodium bicarbonate in the management of certain pharmacological toxicities: sodium channel
blockers, salicylates, methanol and ethylene glycol poisonings, and, finally, miscellaneous pharmacological toxicities.
Hanukoglu et al., "Mutations in subunits of the epithelial sodium channel
cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1," Nature Genetics, vol.
Abnormal splicing of cardiac sodium channel
mRNA is a possible mechanism for the decreased sodium current in arrhythmia.
Epithelial sodium channel
(ENaC) mediates sodium transport across the apical membrane of epithelia and is considered the predominant site for regulating sodium reabsorption in kidney, lung, colon, and sweat glands .
Another emerging area of personalized pain management is the screening of individuals with neuropathic pain for mutations in sodium channel