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Sister chromatid exchanges is a more sensitive indicator of genotoxic effects [27].
Evaluations have also been performed for lymphocyte sister chromatid exchanges (SCEs) and micronuclei (MN), but thus far these biomarkers have not been shown to predict cancer (1,2).
Estrogen effects on chromosome number and sister chromatid exchanges in uterine epithelial cells and kidney cells from neonatal mice.
3]; PDT, population doubling time; PHA, phytoheamagglutinin; SCE, sister chromatid exchanges
The present results showed a significant increase in the mean frequency of chromosomal aberrations (CAs) in traffic policemen when compared to the controls, similar to the earlier studies (18-22) which reported a significant increase in the frequency of chromosomal aberrations, sister chromatid exchanges and micronuclei in traffic policemen.
Fluoxymesterone neither induced chromosomal aberrations (Table 1 and 2) and sister chromatid exchanges (Table 4) nor affected mitotic index (Table 1 and 2) and replication index (Table 4) at significant level even at the highest tested dose i.
Rosenkranz HS, Ennever FK, Dimayuga M, Klopman G, Significant differences in the structural basis of the induction of sister chromatid exchanges and chromosomal aberrations in Chinese hamster ovary cells.
An early study indicated that superoxide dismutase (SOD) and catalase (CAT) could prevent arsenic (As)-induced sister chromatid exchanges (SCEs) in cultured human lymphocytes (1).
Using Syrian hamster embryo (SHE) cells, phenol induced morphologic transformations, gene mutations at two loci (both ouabain-resistant and 6-thioguanine-resistant mutant frequencies were increased), chromosomal aberrations, sister chromatid exchanges, and unscheduled DNA synthesis (63).
In cultured Chinese hamster ovary (CHO) cells, THC induced sister chromatid exchanges at the highest dose tested in the presence of S9; at this dose level, cell cycle delay indicative of toxicity was observed.