Effects of 9-cis-RA and 1,25[(OH).sub.2][D.sub.3] on the mRNA Expression of the SOX10
and MBP Genes
The chromatin analysis revealed that in both fetal cells and a subpopulation of breast tumor cells, the same areas of the genome were becoming accessible--areas where a master gene regulator called Sox10
is known to bind to DNA to initiate a variety of developmental processes.
Oncocytic carcinoma, salivary duct carcinoma, and mucoepidermoid carcinoma all are SOX10
Inactivating mutations in SOX10
cause Waardenburg syndrome, a rare disorder characterized by pigmentation abnormalities and hearing impairment.
These subgroups were characterized by divergent expression of, e.g., EMT-associated genes (CDH2, COL1A2, COL5A2, FN1, MAP1B, MMP3, SOX10
, SPP1, ZEB1, and ZEB2), DNA repair genes (RAD51) (21) or targets relevant for cancer therapy.
Several genes, including RET gene, Endothelin-3 and Endothelin type B receptor, transcription factors such as SOX10
, PHOX2B or ZFHX1B are implicated in its pathogenesis.
They then performed a transcription factor screening assay and found three transcription factors out of those 10 that are required for melanocytes: SOX10
, MITF, and PAX3, a combination dubbed SMP3.
The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10
Other neural crest specifiers such as Sox9 and Sox10
persist in the postmigratory neural crest, where they regulate processes of terminal differentiation.